Secondary and tertiary clinical outcomes
| Outcome parameter | Month −3 | Month 0 | Month 8 | Month 12 | Change from baseline to month 8 (P value) | Change from baseline to month 12 (P value) | |
| EDSS | Median (min-max) | 2.0 (0–3.5) | 1.5 (0–4) | 1.5 (0–3) | 1 (0–3) | P=0.2312 | P=0.0474 |
| SNRS | Median (min-max) | 94 (78–100) | 95 (77–100) | 97 (83–100) | 97 (85–100) | P=0.5493 | P=0.0041 |
| MSFC | Median (min-max) | −0.02 (−0.92 to 1.11) | 0.26 (−1.08 to 1.45) | 0.67 (−0.89 to 1.84) | 0.65 (−0.89 to 1.98) | P=0.0002 | P=0.0385 |
| PASAT (z-scores) | Median (min-max) | 0.28 (−1.68 to 1.13) | 0.79 (−2.37 to 1.13) | 0.96 (−1.94 to 1.13) | 0.96 (−1.85 to 1.13) | P=0.1672 | P=0.0559 |
| SDMT | Median (min-max) | 0.50 (−1.00 to 2.50) | 1.00 (−1.00 to 2.50) | 1.50 (−0.50 to 3.00) | 1.00 (−0.50 to 2.50) | P<0.0001 | P=0.0118 |
| FSS | Median (min-max) | 3.78 (1.00–6.56) | 3.11 (1.00–5.56) | 3.00 (1.00–6.56) | 3.33 (1.00–6.89) | P=0.2617 | P=0.6145 |
| HAQUAMS total | Median (min-max) | 1.68 (1.00–3.26) | 1.63 (1.00–3.05) | 1.56 (1.00–2.47) | 1.50 (1.08–3.17) | P=0.0041 | P=0.0159 |