Aß40 assays | CS n=52 | Pro-DLB n=33 | DLB-d n=43 | Pro-AD n=60 | AD-d n=281 | |||||||
Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | |||
Aß40§ (ng/L) | 9923 | 3084 | 9157 | 3021 | 8070 | 3489 | 13 613 | 4576 | 10 969 | 3873 | F=16.08 P<0.0001 | CS, Pro-DLB, DLB-d<pro AD; DLB-d<AD d; pro-AD>AD-d |
Aß42/Aß40 | 0.110 | 0.0336 | 0.102 | 0.0307 | 0.089 | 0.0402 | 0.050 | 0.0176 | 0.059 | 0.0241 | F=63.78 P<0.0001 | CS, pro-DLB, DLB-d>pro-AD, AD-d; CS>DLB-d |
*Tukey post-hoc test for ANOVA (F), Kruskall-Wallis post-hoc test (H).
†Age at time lumbar of puncture and cognitive evaluation. Mean and SD.
‡Mean and SD.
§Aβ40 Innotest values: Aβ40 values were calculated with the equation: (Innotest Aβ1–40)=0.66 × (IBL Aβ1–40)+923 for centres using IBL kit (Paris, Montpellier, Lille and Rouen).
Aβ40, beta amyloid 1–40; AD, Alzheimer’s disease; AD-d, AD at demented stage; ANOVA, analysis of variance; CS, control subjects; DLB-d, dementia with Lewy bodies at demented stage; M, male; MMSE, Mini-Mental State Examination; Ph-Tau, phosphorylated tau; pro-AD, AD at prodromal stage; Pro-DLB, DLB at prodromal stage.