Functional imaging (SPECT) studies in POE
Study | Year | Participants (n) | Timing | Key results |
Mellers et al 38 | 1998 | 12 IIP, 16 EPY-NP, 11 SCZ | Interictal SPECT | IIP group displayed hypoperfusion in left superior temporal gyrus during verbal fluency compared with word repetition relative to EPY-NP and SCZ groups. |
Fong et al 40 | 2002 | 6 PIP | Psychosis SPECT | Lateral temporal hyperperfusion during PIP |
Leutmezer et al 41 | 2003 | 5 PIP | Psychosis SPECT | Bifrontal and bitemporal hyperperfusion during PIP |
Guarnieri et al 39 | 2005 | 21 IIP or PIP, 23 TLE-NP | Interictal SPECT | No significant differences. Trend for rCBF increase in right posterior cingulate in the POE group |
Nishida et al 42 | 2006 | 17 PIP, 5 postictal mania | Psychosis SPECT | Hyperperfusion in the temporal and/or frontal lobes during PIP; three patients with PIP showed increased perfusion in areas ipsilateral to the predicted epileptogenic zone. |
Oshima et al 43 | 2011 | 5 PIP | Psychosis SPECT | Three patients showed relative hyperperfusion in right temporal lobe during PIP. |
EPY-NP, epilepsy without psychosis; IIP, interictal psychosis; PIP, postictal psychosis; POE, psychosis of epilepsy; rCBF, regional cerebral blood flow; SCZ, schizophrenia; SPECT, single photon emission computed tomography; TLE-NP, temporal lobe epilepsy without psychosis.