Table 2

Functional imaging (SPECT) studies in POE

Study	Year	Participants (n)	Timing	Key results
Mellers et al 38	1998	12 IIP, 16 EPY-NP, 11 SCZ	Interictal SPECT	IIP group displayed hypoperfusion in left superior temporal gyrus during verbal fluency compared with word repetition relative to EPY-NP and SCZ groups.
Fong et al 40	2002	6 PIP	Psychosis SPECT	Lateral temporal hyperperfusion during PIP
Leutmezer et al 41	2003	5 PIP	Psychosis SPECT	Bifrontal and bitemporal hyperperfusion during PIP
Guarnieri et al 39	2005	21 IIP or PIP, 23 TLE-NP	Interictal SPECT	No significant differences. Trend for rCBF increase in right posterior cingulate in the POE group
Nishida et al 42	2006	17 PIP, 5 postictal mania	Psychosis SPECT	Hyperperfusion in the temporal and/or frontal lobes during PIP; three patients with PIP showed increased perfusion in areas ipsilateral to the predicted epileptogenic zone.
Oshima et al 43	2011	5 PIP	Psychosis SPECT	Three patients showed relative hyperperfusion in right temporal lobe during PIP.

EPY-NP, epilepsy without psychosis; IIP, interictal psychosis; PIP, postictal psychosis; POE, psychosis of epilepsy; rCBF, regional cerebral blood flow; SCZ, schizophrenia; SPECT, single photon emission computed tomography; TLE-NP, temporal lobe epilepsy without psychosis.