Summary of CSF cytokine/chemokine profiles in patient groups
| Cytokines/Chemokines | MOG-IgG vs AQP4-IgG | MOG-IgG | AQP4-IgG | MOG-IgG | AQP4-IgG | MS vs control | |
| vs MS | vs control | ||||||
| Th1 | IFN-γ | – | >> | > | > | – | – |
| TNF-α | – | > | – | > | – | – | |
| IP-10 | – | – | – | > | >> | >> | |
| IL-2 | – | – | – | – | – | >> | |
| Th2 | IL-4 | – | – | – | – | – | – |
| IL-5 | – | – | – | – | – | – | |
| IL-13 | – | > | > | >> | >> | – | |
| Eotaxin | – | – | – | – | – | – | |
| Th17 | IL-6 | – | >> | >> | >> | >> | – |
| IL-7 | – | – | – | – | – | – | |
| IL-8 | – | >> | >> | >> | >> | >> | |
| IL-17A | – | – | – | – | – | – | |
| G-CSF | – | >> | – | >> | – | – | |
| GM-CSF | – | >> | >> | >> | >> | – | |
| Treg | IL-10 | – | >> | >> | – | – | – |
| Th9 | IL-9 | – | – | – | > | – | – |
| Others | IL-1β | – | – | – | – | – | – |
| IL-1ra | – | >> | >> | >> | > | – | |
| IL-12 (p70) | – | – | – | – | – | – | |
| IL-15 | – | – | > | – | – | – | |
| FGF basic | – | – | – | >> | >> | >> | |
| MCP-1 | – | >> | >> | – | – | – | |
| MIP-1α | – | >> | >> | >> | > | – | |
| MIP-1β | – | – | – | >> | >> | > | |
| PDGF-BB | – | – | – | – | – | – | |
| RANTES | – | – | – | – | – | – | |
| VEGF | – | – | – | – | – | >> |
‘ –’ means no significant difference, ‘> ’ means significant difference at p<0.001 and ‘>> ’ means p<0.0001 in the analysis of non-parametric tests (Mann-Whitney U test).
AQP4, aquaporin4; CSF, cerebrospinal fluid; FGF, fibroblast growth factor; G-CSF, granulocyte-colony stimulating factor; GM-CSF, granulocyte monocyte-colony stimulating factor; IFN, interferon; IL, interleukin; IP, IFN-γ inducible protein; MCP, monocyte chemotactic protein; MIP, macrophage inflammatory protein; MOG, myelin oligodendrocyte glycoprotein; MS, multiple sclerosis; PDGF-BB, platelet-derived growth factor-BB; RANTES, regulated on activation normal T cell expressed and secreted; Th, T helper cell; TNF, tumour necrosis factor; Treg, regulatory T cells; VEGF, vascular endothelial growth factor.