Table 2

Group comparison of estimated PET and MRI data between AD patients with high and low AS scores

Patients with AD t P valuesHC
High AS scoresLow AS scores
11C-PBB3 SUVR
 Frontal cortex1.10 (0.11)0.94 (0.09)3.160.006*0.86 (0.04)†
 Lateral temporal cortex1.17 (0.12)1.05 (0.06)2.770.0150.95 (0.04)†‡
 Medial temporal cortex1.09 (0.10)1.02 (0.05)1.560.1400.99 (0.05)†
 Parietal cortex1.08 (0.10)0.97 (0.09)2.160.0480.83 (0.05)†‡
 Occipital cortex1.14 (0.11)1.05 (0.07)1.960.0690.90 (0.03)†‡
 Orbitofrontal cortex1.14 (0.98)0.98 (0.07)3.120.007*0.92 (0.05)†
 Anterior cingulate cortex1.12 (0.17)0.94 (0.10)2.450.0270.91 (0.07)†
11C-PiB SUVR
 Frontal cortex1.96 (0.43)1.79 (0.47)0.800.4381.00 (0.05)†‡
 Lateral temporal cortex1.96 (0.46)1.86 (0.42)0.460.6561.02 (0.04)†‡
 Medial temporal cortex1.56 (0.26)1.50 (0.23)0.520.6111.07 (0.04)†‡
 Parietal cortex1.93 (0.40)1.85 (0.49)0.340.7360.95 (0.05)†‡
 Occipital cortex1.74 (0.31)1.65 (0.27)0.620.5420.97 (0.05)†‡
 Orbitofrontal cortex2.01 (0.45)1.81 (0.46)0.870.3971.01 (0.11)†‡
 Anterior cingulate cortex2.31 (0.57)2.05 (0.56)0.910.3771.17 (0.07)†‡
  • Values are listed as mean (SD).

  • *Low AS scores<high AS scores.

  • †HC<high AS scores.

  • ‡HC<low AS scores (p<0.071).

  • 11 C-PBB3, 11C-pyridinyl-butadienyl-benzothiazole 3; 11C-PiB, 11C-Pittsburgh compound-B; AD, Alzheimer’s disease; AS, Apathy Scale; HC, cognitive healthy control; PET, positron emission tomography; SUVR, standard uptake value ratio.