VariableGD-causing variants (group 1)
n=44
E326K and T369M carriers (group 2)
n=98
Non-carriers
(group 3)
n=1584
Beta* (95% CI)
Group 1 vs 3
P value*
Group 1 vs 3
Beta* (95% CI)
Group 2 vs 3
P value*
Group 2 vs 3
Beta* (95% CI)
Groups 1 and 2 vs 3
P value*
Groups 1 and 2 vs 3
MoCA total score25.9 (2.7)25.0 (3.3)25.2 (3.5)0.28 (−0.78 to 1.33)0.61−0.37 (−1.07 to 0.32)0.29−0.18 (−0.77 to 0.41)0.54
  • Scores in first three columns are means (SD) except for categorised MoCA, which is N (%). ORs are calculated such that increasing values (and increasing odds) are associated with worse cognition.

  • *Adjusted for age, gender, disease duration and years of education.

  • †Mild cognitive impairment  classification based on education adjusted score of  22–23 and dementia based on a MoCA education adjusted test score of  < 22.

  • GD, Gaucher’s disease.