Table 4

Cognitive and behavioural impairment in the GBA-associated Parkinson’s disease cohort based on the Movement Disorder Society Unified Parkinson’s disease rating scale part 1 scores dichotomised at 1 or above

VariableGD-causing variants (group 1)
n=44
E326K and T369M carriers (group 2)
n=98
Non-carriers
(group 3)
n=1584
OR*
(95% CI)
Group 1 vs 3
P value*
Group 1 vs 3
OR*
(95% CI)
Group 2 vs 3
P value*
Group 2 vs 3
OR*
(95% CI)
Groups 1 and 2 vs 3
P value*
Groups 1 and 2 vs 3
Cognitive impairment16 (36.4%)36 (36.7%)620 (39.6%)0.96 (0.51 to 1.81)0.890.93 (0.61 to 1.43)0.740.94 (0.65 to 1.35)0.73
Hallucinations and psychosis6 (13.6%)8 (8.2%)137 (8.8%)1.70 (0.70 to 4.13)0.241.00 (0.47 to 2.11)11.21 (0.68 to 2.17)0.52
Depressed mood17 (38.6%)35 (35.7%)574 (36.6%)1.01 (0.54 to 1.87)0.980.95 (0.62 to 1.46)0.830.97 (0.68 to 1.39)0.87
Anxious mood22 (50.0%)46 (46.9%)769 (49.1%)0.95 (0.52 to 1.75)0.880.90 (0.60 to 1.37)0.630.92 (0.65 to 1.30)0.63
Apathy13 (29.5%)38 (38.8%)464 (29.7%)0.94 (0.48 to 1.82)0.851.48 (0.97 to 2.26)0.0691.29 (0.90 to 1.86)0.16
Impulse control disorders2 (4.5%)9 (9.4%)82 (5.2%)0.66 (0.15 to 2.83)0.581.96 (0.95 to 4.06)0.0701.46 (0.75 to 2.83)0.26
  • Data are presented in the table as n (%).

  • * Adjusted for age, gender and disease duration.

  • GD, Gaucher’s disease.