Table 3

Cognitive impairment in the GBA-associated Parkinson’s disease cohort classified by subdomain based on Montreal Cognitive Assessment (MoCA)

Variable (range of possible scores)GD-causing variants (group 1)
n=44
E326K and T369M carriers (group 2)
n=98
Non-carriers
(group 3)
n=1584
OR* (95% CI)
Group 1 vs 3
P value*
Group 1 vs 3
OR* (95% CI)
Group 2 vs 3
P value*
Group 2 vs 3
OR* (95% CI)
Groups 1 and 2 vs 3
P value*
Groups 1 and 2 vs 3
Visuospatial
(0–5)
4.2 (1.1)4.2 (1.1)4.3 (1.0)1.27 (0.68 to 2.40)0.451.09 (0.71 to 1.66)0.701.14 (0.80 to 1.63)0.48
Attention
(0–6)
5.3 (0.9)5.2 (1.0)5.3 (1.0)1.21 (0.66 to 2.22)0.551.28 (0.86 to 1.90)0.231.25 (0.89 to 1.76)0.19
Language
(0–3)
2.6 (0.5)2.3 (0.7)2.4 (0.8)0.80 (0.42 to 1.51)0.491.40 (0.93 to 2.12)0.111.19 (0.84 to 1.68)0.34
Naming
(0–3)
2.8 (0.4)2.9 (0.3)2.9 (0.3)3.18 (1.32 to 7.67)0.0101.01 (0.45 to 2.25)0.991.53 (0.84 to 2.78)0.17
Recall
(0–5)
2.8 (1.7)2.7 (1.6)2.6 (1.6)1.09 (0.60 to 1.97)0.790.88 (0.60 to 1.28)0.500.93 (0.67 to 1.29)0.67
Orientation
(0–6)
5.8 (0.4)5.8 (0.5)5.9 (0.4)1.67 (0.67 to 4.13)0.271.16 (0.60 to 2.24)0.661.30 (0.75 to 2.24)0.35
Abstraction
(0–2)
1.7 (0.6)1.5 (0.7)1.6 (0.6)1.03 (0.51 to 2.10)0.941.67 (1.08 to 2.58)0.0221.45 (0.99 to 2.13)0.053
MoCA
Normal (%)30 (78.9%)68 (73.9%)1080 (74.2%)0.93 (0.40 to 2.16)0.861.08 (0.65 to 1.78)0.771.04 (0.67 to 1.61)0.87
Mild cognitive impairment or dementia (%)8 (21.1%)24 (26.1%)376 (25.8%)