Table 1

Clinical characteristics comparing patients with early neurological deterioration related to sICH versus no sICH

No sICHsICHP value
(n=89)(n=19)
Age (mean±SD)70.8±15.480.2±15.80.026
Admission systolic blood pressure (mean±SD)144.0±31.0150.8±23.90.370
Arrival to intravenous tPA (mean±SD)57.1±27.849.3±15.70.330
Onset to intravenous tPA (mean±SD)141.7±56.9128.3±60.20.362
Admission NIHSS (median, IQR)7 (5–15)14 (10–21)0.016
24-hour NIHSS (median, IQR)5 (1–10)24 (15–26.0)<0.001
Time to new symptoms from tPA (mean±SD)4.8±6.07.3±5.30.099
Time to repeat scan (mean±SD)5.2±6.07.7±5.40.098
Sex (% male)39 (43.8%)10 (52.6%)0.484
Hypertension (%)71 (79.8%)17 (89.5%)0.323
Diabetes (%)23 (25.8%)7 (36.8%)0.331
Hyperlipidaemia (%)55 (61.8%)13 (68.4%)0.587
Coronary artery disease (%)20 (22.5%)6 (31.6%)0.399
History of stroke (%)24 (27.0%)2 (10.5%)0.128
Congestive heart failure (%)8 (9.0%)2 (10.5%)0.834
Smoking (%)22 (24.7%)2 (10.5%)0.177
Anticoagulant on admission (%)5 (5.6%)0 (0.0%)0.346
Antiplatelet on admission41 (46.1%)12 (63.2%)0.176
Thrombectomy (%)33 (37.1%)10 (52.6%)0.209
tPA infusion stopped (%)22 (24.7%)1 (5.3%)0.06
Change in level of consciousness (%)19 (21.3%)15 (78.9%)<0.001
Worsening/new symptoms (%)38 (42.7%)1 (5.3%)0.002
Headache/nausea/vomiting (%)21 (23.6%)4 (21.1%)0.811
Discharge mRS (mean±SD)4.4±1.95.4±0.50.058
90-day mRS (mean±SD)3.0±2.25.8±0.8<0.001
  • mRS, modified Rankin Scale; NIHSS, National Institute of Health Stroke Scale; sICH, symptomatic intracranial haemorrhage; tPA, tissue plasminogen activator.