Table 3

Number of patients displaying a disorder using the Ardouin Scale (score ≥2) before surgery (baseline) and at endpoint visit (3–10 years after surgery)

DisordersBaseline (%)Endpoint (%)P value
Hypodopaminergic behaviours
Depressed mood4 (5.8)9 (13)0.167
 Anxiety14 (20.3)7 (10.1)0.096
 Irritability, aggressiveness7 (10.1)2 (2.9)0.166
 Hyperemotivity21 (30.4)13 (18.8)0.285
 Apathy2 (2.9)17 (24.6)<0.01
Neuropsychiatric non-motor fluctuations
 ON26 (37.7)1 (1.4)<0.01
 OFF27 (39.1)7 (10.1)<0.01
Hyperdopaminergic behaviours
Hypomanic mood6 (8.7)0 (0)<0.01
 Psychotic symptoms0 (0)4 (5.8)0.066
 Nocturnal hyperactivity24 (34.8)8 (11.6)<0.01
 Diurnal somnolence10 (14.5)7 (10.1)0.177
 Eating behaviour20 (29)12 (17.4)0.174
 Creativity12 (17.4)3 (2.9)<0.01
 Hobbyism19 (17.5)2 (2.9)<0.01
 Punding2 (2.9)1 (1.4)0.463
 Risk-taking behaviour5 (7.2)0 (0)<0.05
 Compulsive shopping4 (5.8)2 (2.9)<0.05
 Pathological gambling4 (5.8)0 (0)<0.05
 Hypersexuality2 (2.9)3 (4.3)0.444
 Dopaminergic addiction10 (14.5)0 (0)<0.01
 Excess in motivation25 (36.2)2 (2.9)<0.01