Lowest, ≤35 (n=13) | Middle, 36–40 (n=17) | Highest, ≥41 (n=14) | P value | |
Clinical profile | ||||
Age (years) | 62.2 (7.8) | 63.7 (6.5) | 58.7 (6.3) | 0.138 |
Sex (male:female) | 9:4 | 10:7 | 7:7 | 0.597 |
BMI | 22.2 (3.6) | 22.9 (3.6) | 22.4 (2.2) | 0.814 |
Disease duration (months) | 20.2 (14.3) | 22.1 (21.1) | 12.7 (9.6) | 0.260 |
MRC sum score (range 0–80) | 55.8 (15.5)a,b | 68.0 (5.0)a | 72.0 (5.5)b | <0.001 |
ALSFRS-R score | ||||
Total (range 0–48) | 25.7 (11.7)a,b | 38.3 (1.4)a | 42.7 (1.8)b | <0.001 |
Hand (range 0–12) | 4.5 (2.6)a | 8.6 (1.8)a | 10.4 (1.5)a | <0.001 |
SHI | ||||
SHICMAP | 3.1 (3.2)a | 4.7 (3.6) | 5.6 (3.7)a | 0.050 |
SHImEI | 67.4 (32.0)a,b | 47.3 (25.9)a | 42.5 (21.3)b | 0.002 |
The values are presented as mean±SD.
*Means with the same letters are significantly different (Tukey’s honestly significant difference test).
ALSFRS-R, Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised; BMI, body mass index; CMAP, compound muscle action potential; mEI, muscle echo intensity; MRC, Medical Research Council; SHI, split hand index.