Sex (M/F) | Age |
MYD88 L265P mutation | B-cell clonality testing | Percentage bone marrow infiltration based on histology | Percentage bone marrow infiltration based on flow cytometry* | Serum IgM level (g/L) | Titrated MAG level above 1500 if available (BTU)† | Subjective duration of disease (years)‡ | EMG-based duration of disease (years)‡ |

M | 64 | Negative | Negative | Negative | Negative | 1.7 | n.t. | 0 | 0 |

M | 67 | Negative | Negative | Negative | Negative | 2.3 | n.t. | 8 | 8 |

M | 76 | Negative | Negative | Negative | Negative | 8.1 | >7000 | 1 | 0 |

F | 66 | Negative | Negative | Negative | <1% | 5.4 | >70 000 | 1 | 0 |

M | 62 | Negative | Negative | Negative | n.t. | 4 | >70 000 | 1 | 0 |

M | 73 | Negative | Negative | Negative | Negative | 2.3 | n.t. | 11 | 1 |

F | 72 | Negative | Positive | <5% | n.t. | 9 | >7000 | 3 | 0 |

M | 71 | Negative | Positive | Negative | 1% | 5.7 | >70 000 | 6 | 4 |

M | 72 | Positive | Negative | n.t. | <3 | >70 000 | 1 | 0 | |

F | 43 | Positive | <5% | n.t. | 7 | >70 000 | 11 | 0 | |

M | 70 | Positive | Negative | n.t. | <3 | >7000 | 4 | 3 | |

F | 74 | Positive | Negative | n.t. | <3 | >70 000 | 11 | 5 | |

M | 62 | Positive | <10% | n.t. | 10 | >70 000 | 12 | 4 | |

M | 71 | Positive | 25 | n.t. | 3 | >70 000 | 1 | 0 | |

M | 66 | Positive | Negative | 2% | 5 | >70 000 | 26 | 9 | |

M | 64 | Positive | <5% | 3% | 16 | n.t. | 11 | 6 | |

F | 79 | Positive | Negative | 4% | 5.7 | n.t. | 13 | 13 | |

F | 59 | Positive | Negative | n.t. | 4.7 | n.t. | 5 | 5 | |

F | 75 | Positive | <10% | 5% | 3.16 | n.t. | 4 | 0 | |

M | 70 | Positive | 2% | Negative | 0.6 | n.t. | 3 | 1 |

*While bone marrow histology was performed in all cases, additional flow cytometry of the bone marrow was available in a subset of 11 cases.

†While all patients had an anti-MAG titre of at least 1500 BTU, additional titration above that level was available for a subset of 12 patients.

‡Duration of disease at the time of bone marrow sampling based on subjective onset of symptoms.

BTU, Bühlmann titre units; n.t., not tested.