Table 1

Demographic and clinical characteristics of study population

ParameterNEDA (n=39)EDA (n=46)
Sex (female/male)32/727/19*
Age at baseline scan†42 (25–70)37 (18–52)*
Age at disease onset†34 (23–59)30 (16–46)*
Age at diagnosis†36 (23–61)32 (17–49)*
Disease duration at first scan†7 (0.35–24)7 (0.49–29)
Duration between first and final scan†2.86 (2–5)3.03 (2–4.6)
Baseline EDSS‡1.50 (0–3.5)1.50 (0–4)
Final EDSS‡1.00 (0–3.5)1.75 (0–4)*
Baseline T25FW§4.39 (3.22–7.55)4.29 (3.15–6.65)
Final T25FW§4.43 (3.5–6.85)4.53 (3.10–6.35)
Baseline T2LV¶7.1 (0.22–34.5)9.9 (0.44–66.4)
Final T2LV¶7 (0.15–30.4)11.7 (0.35–70.6)
  • *P<0.05 for comparison to NEDA population.

  • †Mean, years (range).

  • ‡Median.

  • §Mean, seconds (range).

  • ¶Mean, cm3 (range).

  • EDA, evidence of disease activity; EDSS, Expanded Disability Status Scale; NEDA, no evidence of disease activity; T25FW, timed 25-foot walk; T2LV, T2 lesion volume