Table 3

Change in diffusion tensor imaging parameters within selected anatomical structures

Region of interestFractional anisotropyMean diffusivity (mm2s−1×10−3)
Average yearly % changeP valuesAverage yearly % changeP values
NEDA
 Corpus callosum−0.43 * 1.31 ***
 Cingulum−0.77 * 0.94 **
 Superior corona radiata−0.52 * 1.54 **
 Internal capsule−0.59 * 1.17 *
 External capsule0.060.80.170.9
 Brainstem corticospinal tract−0.250.40.950.5
 Middle cerebellar peduncles−0.180.3−0.140.3
EDA
 Corpus callosum−1.24 **** 1.42 ****
 Cingulum−1.46 *** 0.99 **
 Superior corona radiata−1.57 **** 1.65 ****
 Internal capsule−1.14 **** 0.93 ***
 External capsule−1.12 *** 0.94 *
 Brainstem corticospinal tract−0.53 * 0.190.2
 Middle cerebellar peduncles−0.66 *** −0.130.27
  • *P≤0.05, **P≤0.01, ***P≤0.001, ****P≤0.0001.

  • EDA, evidence of disease activity; NEDA, no evidence of disease activity.