Table 1

Data used to determine the Reliable Change Index (RCI) for the primary and secondary outcome measures of distress in trials

Trial	Outcome measure/s		S₁	r_xx *	S_E	S_diff	RCI
Thompson et al (2010)26	Primary	mBDI15	12.51	0.88	4.33	6.13	12.00
Thompson et al (2010)26	Secondary	PHQ-916	7.06	0.89	2.34	3.31	6.49
Ciechanowski et al (2010)27	Primary	HSCL-2017	0.59	0.85	0.23	0.32	0.63
Schröder et al (2014)12†	Primary	BDI-I18	10.37	0.86	3.88	5.49	10.76
Gandy et al (2014)11†	Primary	NDDI-E19	3.59	0.85	1.39	1.96	3.85
		HADS-D29	4.00	0.82	1.70	2.40	4.70
	Secondary	HADS-A29	3.76	0.83	1.55	2.19	4.29
Thompson et al (2015)22	Primary	mBDI15	9.42	0.88	3.26	4.62	9.05
Thompson et al (2015)22	Secondary	PHQ-916	3.63	0.89	1.20	1.70	3.34

The designation of outcome measures as being the primary or secondary outcome measure was taken directly from trial reports, except for Gandy et al (2014)11 (see Outcome assessment section).
*Internal consistency for: mBDI,15 PHQ-9,16 HSCL-20,17 BDI-I,18 NDDI-E,19 HADS-D and HADS-A.20
†The extent of reliable change in and across the trials was also calculated when participants from the trials who did not have a score indicative of clinically significant depression at baseline were excluded. There were such participants in only the Schröder et al 12 (2014) (n=3 intervention and n=5 control participants) and Gandy et al 11 (2014) (n=9 intervention and n=9 control participants) trials. The exclusion of these participants meant the individual RCIs for these two trials needed to be recalculated as the SD of the trial samples on the primary outcome measure of interest for the trial changed. The recalculaed RCI was 9.23 for Schröder et al 12 (2014) and 2.41 for Gandy et al 11 (2014).
BDI, Beck Depression Inventory; HADS-A, Hospital Anxiety and Depression Scale–Anxiety subscale; HADS-D, Hospital Anxiety and Depression Scale–Depression subscale; HSCL-20, Hopkins Symptom Checklist-20; mBDI, modified Beck Depression Inventory; NDDI-E, Neurological Disorders Depression Inventory for Epilepsy; PHQ-9, Patient Health Questionnaire-9; r_xx, reliability of the scale; S₁, SD at pre-treatment; S_diff, SE of difference; S_E, SE of measurement. Individual patient data for the secondary outcome measure NDDI-E within Thompson et al 22 (2015) were not made available for analysis.