Univariate and multivariate analyses assessing the effects of baseline variables on 6-month CDP at 2 years
| Covariate | Unit | Univariate analysis | Multivariate analysis | ||
| HR (95% CI) | P values | HR (95% CI) | P values | ||
| Treatment (fingolimod vs placebo) | – | 0.55 (0.39 to 0.76) | <0.001 | 0.56 (0.40 to 0.78) | 0.001 |
| NBV | 100 mm3 | 0.72 (0.60 to 0.87) | 0.001 | 0.76 (0.62 to 0.92) | 0.006 |
| Screening PASAT score | 1 point | 0.98 (0.97 to 0.99) | 0.015 | 0.99 (0.98 to 1.01) | 0.15 |
| Learning ability (high vs low) | – | 0.88 (0.64 to 1.23) | 0.46 | 0.95 (0.68 to 1.33) | 0.78 |
CDP, confirmed disability progression; NBV, normalised brain volume; PASAT, Paced Auditory Serial Addition Test.