Table 4

Comparison of per-year progression rates within the two cohorts using the two approaches: multilevel random slope and intercept models (MLMs) versus pattern-mixture models (PMMs)

ClusterTracking Parkinson's cohortDiscovery cohort
MLM slope estimate
(95% CI)
PMM slope estimate
(95% CI)
MLM slope estimate
(95% CI)
PMM slope estimate
(95% CI)
13.16 (2.76 to 3.55)3.08 (2.70 to 3.45)2.76 (2.30 to 3.22)2.66 (2.20 to 3.13)
MDS-UPDRS III22.56 (2.18 to 2.95)2.62 (2.23 to 3.01)2.25 (1.63 to 2.86)2.29 (1.72 to 2.87)
32.48 (1.99 to 2.97)2.66 (2.02 to 3.31)1.81 (1.26 to 2.37)1.79 (1.13 to 2.46)
40.61 (0.11 to 1.11)0.65 (0.09 to 1.21)1.61 (1.08 to 2.15)1.67 (1.04 to 2.30)
P values<0.001<0.0010.0070.04
1−0.16 (−0.26 to −0.06)−0.20 (−0.32 to −0.09)−0.19 (−0.30 to −0.07)−0.21 (−0.33 to −0.09)
MoCA adjusted2−0.02 (−0.12 to 0.08)−0.04 (−0.12 to 0.04)−0.10 (−0.25 to 0.05)−0.09 (−0.24 to 0.05)
3−0.22 (−0.34 to −0.09)−0.31 (−0.50 to −0.13)−0.27 (−0.41 to −0.14)−0.34 (−0.53 to −0.14)
4−0.04 (−0.17 to 0.08)−0.10 (−0.29 to 0.08)−0.17 (−0.30 to −0.04)−0.20 (−0.34 to −0.06)
P values0.040.0170.410.26
11.63 (1.46 to 1.81)1.61 (1.44 to 1.78)1.43 (1.22 to 1.64)1.44 (1.21 to 1.67)
MDS-UPDRS II21.25 (1.08 to 1.42)1.32 (1.13 to 1.51)1.01 (0.73 to 1.28)0.94 (0.68 to 1.19)
31.51 (1.29 to 1.74)1.68 (1.33 to 2.02)1.25 (1.01 to 1.49)1.41 (1.08 to 1.74)
41.14 (0.92 to 1.37)1.32 (1.02 to 1.62)1.25 (0.99 to 1.51)1.34 (1.04 to 1.63)
P values0.0010.060.130.02
  • Cluster 1 is fast motor progression; cluster 2 is mild motor and non-motor disease; cluster 3 is severe motor disease, poor psychological well-beingand poor sleep; cluster 4 is slow motor progression.

  • MDS, Movement Disorders Society; MoCA, Montreal Cognitive Assessment; UPDRS, Unified Parkinson’s Disease Rating Scale.