Table 3

Diffusion metrics of structural connectivity-based thalamic parcellation in 11 patients with ALS at baseline (T1) and 6-month follow-up (T2)

Thalamic parcellation	Hemis phere	Time point	FA		MD (×10^–3)		RD (×10^–3)		AD (×10^–3)
Thalamic parcellation	Hemis phere	Time point	Mean	SD	Mean	SD	Mean	SD	Mean	SD
Frontal lobe	L	T1	0.3	0.02	0.85	0.07	0.97	0.08	1.1	0.07
		T2	0.3	0.03	0.86	0.08	0.98	0.08	1.12	0.08
	R	T1	0.3	0.02	0.87*	0.07	0.99*	0.07	1.12*	0.07
		T2	0.3	0.03	0.92	0.1	1.04	0.1	1.18	0.1
Premotor cortex (BA6)	L	T1	0.33	0.03	0.72	0.04	0.83	0.04	0.96	0.04
		T2	0.35	0.03	0.7	0.03	0.82	0.03	0.96	0.03
	R	T1	0.35	0.03	0.72	0.04	0.84	0.04	0.99	0.05
		T2	0.35	0.03	0.72	0.02	0.84	0.03	0.98	0.03
Motor cortex (BA4)	L	T1	0.36	0.03	0.71	0.03	0.82	0.03	1	0.04
		T2	0.38	0.02	0.7	0.02	0.82	0.02	1.01	0.03
	R	T1	0.36	0.03	0.72	0.02	0.83	0.02	1.02	0.04
		T2	0.36	0.03	0.71	0.03	0.82	0.03	1	0.05
Somatosensory cortex	L	T1	0.4	0.05	0.72	0.03	0.84	0.04	1.05	0.06
		T2	0.4	0.06	0.72	0.03	0.84	0.04	1.06	0.07
	R	T1	0.4	0.06	0.73	0.04	0.84	0.04	1.07	0.06
		T2	0.4	0.06	0.73	0.03	0.84	0.03	1.07	0.07
Parietal lobe	L	T1	0.34	0.03	0.75	0.04	0.87	0.04	1.03	0.04
		T2	0.36	0.04	0.75	0.04	0.88	0.04	1.05	0.04
	R	T1	0.34	0.02	0.78	0.03	0.89	0.04	1.06	0.05
		T2	0.34	0.03	0.77	0.04	0.89	0.04	1.05	0.04
Temporal lobe	L	T1	0.27	0.03	1.08*	0.13	1.19*	0.14	1.37*	0.14
		T2	0.26	0.03	1.18	0.15	1.29	0.15	1.48	0.15
	R	T1	0.27	0.02	1.15*	0.21	1.27*	0.22	1.45*	0.25
		T2	0.26	0.04	1.21	0.21	1.33	0.22	1.5	0.23
Occipital lobe	L	T1	0.35	0.07	0.8	0.2	0.92	0.2	1.09	0.21
		T2	0.34	0.09	0.82	0.21	0.94	0.2	1.11	0.19
	R	T1	0.34	0.03	0.77	0.09	0.88	0.1	1.05	0.13
		T2	0.35	0.05	0.77	0.09	0.89	0.1	1.06	0.11

*Indicates significant change between T1 and T2, p<0.05.
AD, axial diffusivity; ALS, amyotrophic lateral sclerosis; FA, fractional anisotropy; L, left; MD, mean diffusivity; R, right; RD, radial diffusivity.