Table 2

Exploratory network differences between different groups

HCRRMSPPMS
RC95% CIP valuesRC95% CIP valuesRC95% CIP values
Edge density
 MS−0.65(−1.69 to 0.38)0.210
 RRMS−0.71(−1.84 to 0.42)0.219
 PPMS−0.72(−2.1 to 0.67)0.310−0.011(−1.27 to 1.25)0.987
 SPMS−0.45(−1.78 to 0.88)0.5070.258(−0.93 to 1.43)0.6700.27(−1.12 to 1.66)0.707
Global efficiency
 MS−71.23(−129.47 to −13.00) 0.016
 RRMS−33.44(−95.11 to 28.25)0.287
 PPMS−85.82(−161.6 to −9.96) 0.027 −52.38(−121.08 to 16.34)0.135
 SPMS−145.34(−218.38 to −72.28) 0.0001 −111.90(−176.47 to −47.31) 0.0008 −59.52(−135.72 to 16.67)0.126
Mean local efficiency
 MS−72.53(−138.60 to −6.46) 0.031
 RRMS−30.21(−100.16 to 39.74)0.396
 PPMS−85.68(−171.68 to 0.34)0.051−55.46(−133.39 to 22.47)0.162
 SPMS−158.42(− 241.26 to −75.58) 0.0002 −128.21(−201.44 to −54.96) 0.0007 −72.74(−159.16 to 13.68)0.099
Mean clustering coefficient
 MS−14.84(−19.89 to −9.79) < 0.0001
 RRMS−12.00(−17.51 to −6.48) < 0.0001
 PPMS−13.42(−20.19 to −6.64) 0.0001 −1.42(−7.55 to 4.73)0.650
 SPMS−20.30(−26.84 to −13.76) < 0.0001 −8.30(−14.07 to −2.52) 0.0033 −6.88(−13.69 to −0.06) 0.037
  • Analysis of variance was performed. P values in bold denote statistical significance at p<0.05 when the groups on the left were compared with the reference group (top row) and adjusted for age, gender, lesion load and total intracranial volume.

  • HC, healthy controls; MS,multiple sclerosis; PPMS, primary progressive MS; RC, regression coefficient; RRMS, relapsing–remitting MS; SPMS, secondary progressive MS.