Table 3

Univariate and multivariate analyses assessing the effects of baseline variables on 2-year PBVC

Covariate	Unit	Univariate analysis		Multivariate analysis
Covariate	Unit	Beta*	P values	Beta*	P values
Treatment (fingolimod vs placebo)	–	0.41 (0.22–0.59)	<0.001	0.39 (0.21–0.57)	0.001
NBV	100 mm³	0.34 (0.24–0.45)	<0.001	0.30 (0.19–0.40)	0.006
Screening PASAT score	1 point	0.015 (0.007–0.023)	<0.001	0.008 (0.001–0.016)	0.038
Learning ability (high vs low)	–	0.23 (0.06–0.41)	0.01	0.17 (0.006–0.34)	0.058

*Beta: PBVC change associated with the 1-unit change of the independent variable.
NBV, normalised brain volume; PASAT, Paced Auditory Serial Addition Test; PBVC, per cent brain volume change.