Table 2

Analysis of HLA class I and II alleles in anti-NMDAR encephalitis and healthy control

HLA allele	Patients (n=61×2)			Controls (n=571×2)			P value	P_adjvalue*	OR (95% CI)
HLA allele	Positive	Negative	Frequency	Positive	Negative	Frequency	P value	P_adjvalue*	OR (95% CI)
DRB1*16:02	18	104	0.1475	55	1087	0.0482	8.9×10⁻⁵	0.0209	3.41 (1.81 to 6.17)
DQA1*01:02	40	82	0.3279	227	915	0.1988	0.0015	0.1793	1.96 (1.27 to 2.99)
DPA1*135:01	4	118	0.0328	3	1139	0.0026	0.0023	0.1802	12.81 (2.14 to 88.46)
A*02:03	14	108	0.1148	59	1083	0.0517	0.0120	0.6432	2.37 (1.18 to 4.48)
DQB1*05:02	24	98	0.1967	133	1009	0.1165	0.0140	0.6432	1.85 (1.09 to 3.05)
C*03:03	1	121	0.0082	64	1078	0.0560	0.0164	0.6432	0.13 (0.00 to 0.82)
B*38:02	10	112	0.0819	40	1102	0.0350	0.0231	0.7581	2.45 (1.06 to 5.17)
DQB1*03:01	14	108	0.1148	226	916	0.1979	0.0282	0.7581	0.52 (0.27 to 0.94)
DPA1*01:03	23	99	0.1885	319	823	0.2793	0.0321	0.7581	0.59 (0.35 to 0.97)
DPB1*05:01	66	56	0.5409	502	640	0.4396	0.0352	0.7581	1.50 (1.01 to 2.22)
DPB1*02:01	9	113	0.0738	164	978	0.1436	0.0366	0.7581	0.47 (0.20 to 0.95)
DPB1*04:01	3	119	0.0246	86	1056	0.0753	0.0387	0.7581	0.31 (0.06 to 0.96)

The table only shows HLA alleles with an unadjusted p value of less than 0.05.
*P values were adjusted for multiple testing with false discovery rate (FDR) step-up method.
HLA, human leucocyte antigen.