Model summary+predictors | Regression coefficient | 95% CI | P values | |
MRI metrics | ||||
SDMT score | Adj.R2=0.361 | |||
DGM, cm3 | 1.61 | (0.79 to 2.43) | < 0.001 | |
Lesion load, mL | −0.17 | (−0.34 to −0.0014) | 0.048 | |
Female | 12.16 | (5.51 to 18.82) | < 0.001 | |
MRI metrics+network measures | ||||
SDMT score | Adj.R2=0.352 | |||
DGM, cm3 | 1.52 | (0.61 to 2.43) | 0.001 | |
Lesion load, mL | −0.17 | (−0.34 to 0.0069) | 0.059 | |
Edge density, (%) | 0.24 | (−0.75 to 1.23) | 0.624 | |
Female | 11.94 | (5.18 to 18.70) | < 0.001 | |
Adj.R2=0.396 | ||||
DGM, cm3 | 1.93 | (1.21 to 2.65) | < 0.001 | |
Global efficiency | 0.021 | (0.0055 to 0.035) | 0.008 | |
Female | 10.97 | (4.37 to 17.56) | 0.002 | |
Adj.R2=0.380 | ||||
DGM, cm3 | 2.01 | (1.28 to 2.75) | < 0.001 | |
mLE | 0.015 | (0.0028 to 0.028) | 0.018 | |
Female | 11.43 | (4.79 to 18.06) | 0.001 | |
Adj.R2=0.387 | ||||
DGM, cm3 | 1.45 | (0.63 to 2.28) | < 0.001 | |
mCC | 0.21 | (0.047 to 0.38) | 0.013 | |
Female | 9.92 | (2.98 to 16.85) | 0.006 | |
Final model | ||||
SDMT score | Adj.R2=0.396 | |||
DGM, cm3 | 1.93 | (1.21 to 2.65) | < 0.001 | |
Global efficiency | 0.021 | (0.0055 to 0.035) | 0.008 | |
Female | 10.97 | (4.36 to 17.56) | 0.002 |
P values in bold denote statistical significance at p<0.05.
DGM, deep grey matter; SDMT, Symbol Digit Modalities Test; mCC, mean clustering coefficient; mLE, mean local efficiency.