Table 1

Characteristics of studies included in the meta-analysis of prophylactic effect of antiepileptic drugs (AED)

						Prophylactic AED			Placebo or no treatment
Study (year)	Study design	Type of AED	Follow-up	Craniotomy	Histology	Epilepsy	No epilepsy	Total	Epilepsy	No epilepsy	Total
North et al 13 (1983)	Randomised study	Phenytoin	12 months	Yes	Malignant	9	33	42	5	34	39
Franceschetti et al 21 (1990)	Randomised study	Phenytoin+phenobarbital	24 months	Yes	Benignant/ malignant	6	35	41	7	35	42
Glantz et al 18 (1996)	Randomised study	Divalproex sodium	12 months	Mixed with biopsy	Malignant	13	24	37	9	28	37
De Santis et al 22 (2002)	Randomised study	Phenytoin+2 others	1 week	Yes	Benignant/ malignant	13	87	100	11	89	100
Forsyth et al 19 (2003)	Randomised study	Phenytoin	12 months	Mixed with biopsy	Malignant	11	43	54	15	31	46
Lwu et al 15 (2010)	Retrospective study	Phenytoin	12 months	Yes	Malignant	1	43	44	2	64	66
Sughrue et al 16 (2011)	Retrospective study	Levetiracetam and phenytoin	1 month	Yes	Benignant	0	129	129	1	50	51
Garbossa et al 17 (2013)	Retrospective study	Levetiracetam	6 months	Yes	Malignant	8	35	43	9	39	48
Wychowskyi et al 20 (2013)	Retrospective study	Levetiracetam, phenytoin+4 others	12 months	Mixed with biopsy	Malignant	23	44	67	15	30	45
Wu et al 14 (2013)	Randomised study	Phenytoin	12 months	Yes	Malignant	11	51	62	15	46	51
Ansari et al 5 (2014)	Retrospective study	Levetiracetam, phenytoin+4 others	12 months	Yes	Malignant	34	100	134	12	56	68