Table 6

Variation of the treatment effect with year of analysis (MLM)

AnalysisRelative progression rate (%) at year:
246810
Primary analysis cohort
EDSS basis (95% CI)47% (41% to 52%)58% (54% to 62%)66% (63 to 69%)71% (68 to 74%)72% (69 to 74%)
Utility basis (95% CI)36% (31% to 41%)55% (51% to 60%)68% (64 to 72%)76% (73 to 80%)77% (743 to 80%)
RRMS-only subgroup
EDSS basis (95% CI)42% (36% to 48%)55% (51% to 59%)63% (60% to 66%)69% (66% to 72%)69% (67% to 72%)
Utility basis (95% CI)28% (22% to 34%)50% (45% to 55%)62% (58% to 66%)74% (70% to 78%)76% (72% to 79%)
  • EDSS, Expanded Disability Status Scale; MLM, multilevel model; RRMS, relapsing remitting multiple sclerosis.