Analysis | Relative progression rate (%) at year: | ||||
2 | 4 | 6 | 8 | 10 | |
Primary analysis cohort | |||||
EDSS basis (95% CI) | 47% (41% to 52%) | 58% (54% to 62%) | 66% (63 to 69%) | 71% (68 to 74%) | 72% (69 to 74%) |
Utility basis (95% CI) | 36% (31% to 41%) | 55% (51% to 60%) | 68% (64 to 72%) | 76% (73 to 80%) | 77% (743 to 80%) |
RRMS-only subgroup | |||||
EDSS basis (95% CI) | 42% (36% to 48%) | 55% (51% to 59%) | 63% (60% to 66%) | 69% (66% to 72%) | 69% (67% to 72%) |
Utility basis (95% CI) | 28% (22% to 34%) | 50% (45% to 55%) | 62% (58% to 66%) | 74% (70% to 78%) | 76% (72% to 79%) |
EDSS, Expanded Disability Status Scale; MLM, multilevel model; RRMS, relapsing remitting multiple sclerosis.