Table 4

Subgroup analyses by type of MS, date of baseline assessment and baseline EDSS (both models): EDSS outcomes

PopulationnMean yearsMeanMarkov modelMultilevel modelMultilevel model with imputation
At riskOn treatmentBaseline EDSSAbsolute treatment effectRelative rate of progressionAbsolute treatment effectRelative rate of progressionAbsolute treatment effectRelative rate of progression
Primary analysis population48628.77.03.180.12 (0.07, 0.17)93% (90%, 96%)0.61 (0.55, 0.66)72% (69%, 74%)0.65 (0.59, 0.70)73% (70%, 75%)
Baseline EDSS ≤3.529409.07.42.020.35 (0.28, 0.42)84% (81%, 87%)0.63 (0.56, 0.71)74% (71%, 77%)0.67 (0.59, 0.74)75% (73%, 78%)
Baseline EDSS 4–5.512758.66.74.42−0.11 (−0.21, −0.02)110% (102%, 119%)0.59 (0.49, 0.68)68% (63%, 73%)0.64 (0.54, 0.73)69% (65%, 73%)
Baseline EDSS ≥66478.05.56−0.47 (−0.57, −0.36)233% (202%, 265%)0.52 (0.41, 0.62)63% (56%, 70%)0.59 (0.48, 0.69)65% (59%, 71%)
RRMS at baseline42178.97.32.860.25 (0.20, 0.31)86% (83%, 89%)0.68 (0.62, 0.74)69% (67%, 72%)0.71 (0.66, 0.78)71% (69%, 73%)
SPMS at baseline6457.85.15.29−0.76 (−0.86, −0.66)218% (202%, 234%)0.10 (0.00, 0.20)93% (86%, 101%)0.19 (0.09, 0.29)90% (85%, 95%)
RRMS at baseline and:
Baseline EDSS ≤3.528829.07.52.000.39 (0.32, 0.46)82% (79%, 86%)0.67 (0.59, 0.74)73% (69%, 76%)0.70 (0.63, 0.77)74% (71%, 77%)
Baseline EDSS 4–5.510938.77.04.40−0.01 (−0.11, 0.10)101% (91%, 110%)0.68 (0.58, 0.79)63% (58%, 68%)0.72 (0.62, 0.83)65% (60%, 70%)
Baseline EDSS ≥62428.46.26−0.16 (−0.35, 0.04)143% (90%, 196%)0.84 (0.64, 1.03)44% (32%, 56%)0.91 (0.72, 1.10)47% (37%, 58%)
SPMS at baseline and:
Baseline EDSS ≤3.5588.25.92.69−1.48 (−1.87, −1.09)181% (158%, 203%)−1.10 (−1.51, −0.70)151% (133%, 170%)−1.05 (−1.46, −0.64)142% (125%, 159%)
Baseline EDSS 4–5.51827.85.14.55−0.77 (−0.95, −0.59)182% (161%, 202%)−0.01 (−0.20, 0.19)101% (89%, 112%)0.13 (−0.06, 0.32)94% (85%, 102%)
Baseline EDSS ≥64057.85.16−0.65 (−0.77, −0.53)292% (255%, 329%)0.32 (0.21, 0.44)76% (68%, 84%)0.39 (0.28, 0.50)76% (69%, 83%)
Date of baseline assessment
On or before 28 August 200323518.76.93.320.02 (−0.06, 0.10)99% (94%, 103%)0.53 (0.46, 0.61)75% (71%, 78%)0.58 (0.51, 0.66)75% (72%, 79%)
After 28 August 200325118.87.03.050.21 (0.14, 0.29)88% (83%, 92%)0.67 (0.60, 0.75)69% (66%, 72%)0.71 (0.64, 0.78)71% (67%, 74%)
Baseline at or before 31 August 2003 and:
Baseline EDSS ≤3.513528.97.52.070.27 (0.16, 0.38)87% (82%, 92%)0.57 (0.46, 0.68)77% (72%, 81%)0.61 (0.50, 0.72)77% (73%, 82%)
Baseline EDSS 4–5.56318.66.64.42−0.21 (−0.34, −0.08)119% (107%, 131%)0.49 (0.36, 0.62)73% (66%, 80%)0.54 (0.41, 0.66)74% (68%, 80%)
Baseline EDSS ≥63687.95.46−0.50 (−0.64, −0.36)244% (202%, 287%)0.48 (0.34, 0.62)65% (56%, 74%)0.55 (0.41, 0.69)67% (59%, 75%)
Baseline after 31 August 2003 and
Baseline EDSS ≤3.515889.07.41.970.42 (0.32, 0.52)81% (77%, 85%)0.69 (0.59, 0.79)72% (68%, 76%)0.71 (0.61, 0.81)73% (69%, 78%)
Baseline EDSS 4–5.56448.56.84.43−0.02 (−0.16, 0.11)102% (90%, 114%)0.68 (0.54, 0.82)62% (55%, 69%)0.74 (0.60, 0.87)64% (58%, 71%)
Baseline EDSS ≥62798.25.66−0.43 (−0.58, −0.27)219% (175%, 264%)0.57 (0.41, 0.72)61% (50%, 71%)0.63 (0.48, 0.78)63% (54%, 71%)
  • EDSS, Expanded Disability Status Scale; MS, multiple sclerosis; RRMS, relapsing remitting multiple sclerosis; SPMS, secondary progressive multiple sclerosis.