Table 5

Other subgroup analyses (Markov model only)

PopulationnMean yearsMeanEDSSUtility
At riskOn treatmentBaseline
EDSS
Absolute treatment effectRelative rate of progressionAbsolute treatment effectRelative rate of progression
Primary analysis population48628.77.03.180.12 (0.07, 0.17)93% (90%, 96%)0.039 (0.034, 0.044)76% (73%, 79%)
One-way analyses
On treatment throughout28558.78.73.020.46 (0.39, 0.53)73% (69%, 77%)0.073 (0.067, 0.079)55% (51%, 58%)
Ever off-treatment20078.84.63.40−0.36 (−0.44, −0.28)123% (118%, 128%)−0.010 (−0.018, −0.001)106% (101%, 111%)
By gender
Male12248.66.83.19−0.12 (−0.23, 0.00)107% (100%, 114%)0.013 (0.002, 0.024)92% (85%, 99%)
Female36388.87.03.170.20 (0.14, 0.26)88% (84%, 92%)0.048 (0.042, 0.053)71% (67%, 74%)
Baseline at or before 28 February 20039978.77.03.350.03 (−0.09, 0.14)98% (91%, 106%)0.035 (0.024, 0.046)78% (71%, 85%)
Baseline after 28 February 200338658.87.03.130.14 (0.09, 0.20)91% (88%, 95%)0.040 (0.034, 0.045)75% (72%, 79%)
Baseline at or before 31 August 200323518.76.93.320.02 (−0.06, 0.10)99% (94%, 103%)0.033 (0.025, 0.040)79% (75%, 84%)
Baseline after 31 August 200325118.87.03.050.21 (0.14, 0.29)88% (83%, 92%)0.044 (0.037, 0.052)73% (69%, 77%)
Disease duration at baseline
≤3 years12518.87.32.460.45 (0.33, 0.57)77% (71%, 83%)0.060 (0.050, 0.070)65% (59%, 71%)
>3 years36118.76.93.430.00 (−0.05, 0.06)100% (96%, 103%)0.032 (0.026, 0.037)80% (76%, 84%)
≤6 years22958.87.22.670.32 (0.24, 0.40)83% (78%, 87%)0.051 (0.043, 0.058)70% (65%, 74%)
>6 years25678.76.83.64−0.06 (−0.12, 0.01)104% (99%, 108%)0.028 (0.022, 0.035)82% (78%, 86%)
Two-way analyses
Disease duration ≤3 years and:
Baseline EDSS ≤3.59818.97.51.800.60 (0.47, 0.73)73% (67%, 79%)0.068 (0.058, 0.079)61% (55%, 67%)
Baseline EDSS 4–5.51998.46.74.410.00 (−0.29, 0.28)100% (74%, 127%)0.039 (0.009, 0.068)74% (56%, 94%)
Baseline ≥EDSS 6718.05.76−0.35 (−0.76, 0.05)209% (83%, 338%)0.001 (−0.050, 0.051)100% (65%, 135%)
Disease duration >3 years and:
Baseline EDSS ≤3.519599.07.42.120.23 (0.14, 0.31)90% (85%, 94%)0.044 (0.036, 0.051)73% (69%, 78%)
Baseline EDSS 4–5.510768.66.74.43−0.14 (−0.23, −0.04)112% (104%, 121%)0.038 (0.027, 0.048)76% (69%, 82%)
Baseline ≥EDSS 65768.05.46−0.48 (−0.59, −0.37)236% (204%, 268%)−0.021 (−0.038, −0.004)114% (103%, 125%)
  • EDSS, Expanded Disability Status Scale.