Table 1

Participant demographics and clinical characteristics

CharacteristicsParticipants with ALS (n=23)Healthy controls (n=23)
Age, median (range), years67 (45–73)64 (43–76)
Sex, n
 Male1614
 Female79
Site of onset
 Limb20
 Bulbar3
Disease distribution clinically
 Bulbar and limb involvement11
 Limb only involvement12
Disease duration, median (range), months17 (9–39)
Slow vital capacity, median (range), %79 (61–127)
UMN score, median (range), out of a maximum of 16 points8 (3–16)
Total MRC power score, median (range), out of a maximum of 220 points188 (91–220)
ALSFRS-R, median (range), out of a maximum of 48 points40 (25–46)
∆ALSFRS-R, median (range)0.37 (0.09–1.33)
ECAS total, median (range), out of a maximum of 136 points133 (88–135)
  • ALS, amyotrophic lateral sclerosis; ALSFRS-R, Revised ALS Functional Rating Scale; ∆ALSFRS-R, rate of change per month in the Revised ALS Functional Rating Scale; ECAS, Edinburgh Cognitive and Behavioural ALS Screen; MRC, Medical Research Council; UMN, upper motor neuron.