Multivariable analysis of survival predictors
| Crude HR (95% CI) | P value | Adjusted HR (95% CI) | P value | |
| Time to constipation (years) | 0.85 (0.75 to 0.86) | <0.001 | 0.73 (0.64 to 0.84) | <0.001 |
| Time to urinary symptoms (years) | 0.86 (0.81 to 0.91) | <0.001 | 0.88 (0.80 to 0.96) | 0.004 |
| Male gender | 1.23 (0.82 to 1.85) | 0.32 | 1.76 (0.93 to 3.31) | 0.08 |
| Age at onset (years) | 1.05 (1.02 to 1.07) | <0.001 | 0.99 (0.95 to 1.04) | 0.74 |
| Time to falls (years) | 0.86 (0.78 to 0.95) | 0.002 | 0.94 (0.77 to 1.14) | 0.51 |
| PSP phenotype | ||||
| PSP-P (vs RS) | 0.36 (0.21 to 0.63) | <0.001 | 0.20 (0.07 to 0.57) | 0.003 |
| PAGF (vs RS) | 0.23 (0.09 to 0.61) | 0.003 | 0.22 (0.03 to 1.55) | 0.13 |
| Cognitive (vs RS) | 0.74 (0.45 to 1.23) | 0.25 | 0.93 (0.44 to 2.00) | 0.86 |
Cognitive group is a composite of PSP-Speech/Language, PSP-Frontal/Behavioural and PSP-Corticobasal Syndrome groups.
PAGF, pure akinesia with gait freezing; PSP, progressive supranuclear palsy; PSP-P, PSP-parkinsonism; RS, Richardson syndrome.