Hippocampal subfield volume differences at baseline and changes after 18 months
| PD-stable (n=62) | PD-progressors (n=11) | Adjusted P value | |
| Baseline | |||
| Whole hippocampus | 6594.31 (639.71) | 6130.28 (552.76) | 0.040* |
| CA1 | 1191.06 (126.42) | 1111.54 (97.19) | 0.049* |
| Subiculum | 836.40 (91.36) | 777.12 (88.14) | 0.037* |
| Presubiculum | 582.97 (68.31) | 529.62 (72.69) | 0.038* |
| Parasubiculum | 117.20 (17.52) | 117.85 (23.37) | 0.972 |
| GC-DG | 574.90 (64.17) | 539.73 (40.58) | 0.109 |
| Fimbria | 154.33 (38.80) | 135.79 (33.05) | 0.293 |
| % Change after 18 months | |||
| Whole hippocampus | −1.04 (2.13) | −3.08 (1.66) | 0.006** |
| CA1 | −0.77 (2.87) | −2.12 (2.00) | 0.104 |
| Subiculum | −1.70 (2.65) | −2.49 (1.90) | 0.826 |
| Presubiculum | −1.06 (3.06) | −3.50 (2.43) | 0.027* |
| Parasubiculum | 0.43 (6.11) | −3.86 (4.73) | 0.008** |
| GC-DG | −0.73 (3.20) | −3.08 (2.46) | 0.040* |
| Fimbria | −4.52 (8.07) | −11.93 (7.35) | 0.019* |
Analysis of covariance (ANCOVA), controlling for gender, age, education, vascular risk factors, intracranial volume and interval between scans, and adjusted for multiple comparisons using Bonferroni correction.
*p<0.05, **p<0.01.
CA, cornu ammonis subfield CA1; GD-DG, granule cell layer of the dentate gyrus; PD, Parkinson’s disease.