Table 1

Subject characteristics

	Patients with SD, n=162	Controls, n=65	P value
Sex, n male (%)	75 (46%)	32 (49%)	0.69
Age at CSF collection, years	64 (58–68)	65 (60–70)	0.43
Age at onset, years	60 (54–65)*	n/a	n/a
Age at death, years	69 (65–74)†	n/a	n/a
MMSE score	25 (21–28)‡	n/a	n/a
CDR-SB score	3.5 (2.5–4.8)§	n/a	n/a
FTD-CDR-SB score	4.0 (2.0–6.0)¶	n/a	n/a
CSF NfL, pg/mL	2326 (1628–3593)	577 (446–766)	<0.001
Isolated decreased abeta, n (%)	8 (5%)	n/a	n/a
Isolated increased p-tau and/or t-tau, n (%)	61 (38%)	n/a	n/a
MRI available at baseline (at follow-up), n	87 (32)	n/a	n/a

Continuous variables are presented as medians (IQR).
*Unknown in five patients.
†30 patients were known to be deceased at time of data analysis.
‡Available in 135 patients.
§Available in 65 patients.
¶Available in 34 patients.
CDR-SB, Clinical Dementia Rating scale sum of boxes; CSF, cerebrospinal fluid; FTD-CDR-SB, frontotemporal dementia CDR-SB; MMSE, Mini-Mental State Examination; NfL, neurofilament light chain; SD, semantic dementia; abeta, amyloid-β_1-42; p-tau and/or t-tau, phospho-tau and/or total-tau.