Clinical and neuroimaging features of patients with CADASIL with ICH-onset vs IS-onset
| ICH-onset (n=21) | IS-onset (n=46) | P values | |
| Age (at first stroke) | 58.3±9.1 | 57.8±9.9 | 0.85 |
| Male | 14 (66.7) | 28 (60.9) | 0.65 |
| Annual recurrent rate | 10.9/100 person-years | 7.0/100 person-years | 0.03* |
| Recurrence stroke | 12 (57.1) | 17 (37.0) | 0.12 |
| Only IS | 5 | 10 | 0.66 |
| Only ICH | 6 | 6 | |
| Both ICH and IS | 1 | 1 | |
| Mortality | 6 (28.6) | 4 (8.7) | 0.06 |
| Family history of stroke | 11 (52.4) | 19 (41.3) | 0.40 |
| High family burden of stroke | 7 (33.3) | 5 (10.9) | 0.03 |
| Hypertension | 19 (90.5) | 36 (78.3) | 0.23 |
| Diabetes mellitus | 6 (28.6) | 13 (28.3) | 0.98 |
| Hyperlipidaemia | 12 (57.1) | 22 (47.8) | 0.48 |
| Smoking | 7 (33.3) | 20 (43.5) | 0.43 |
| WMH score† | 2.9±0.3 | 2.6±0.7 | 0.16 |
| Anterior temporal WMH | 1 (8.3) | 5 (11.4) | 0.99 |
| External capsule WMH | 10 (83.3) | 30 (68.2) | 0.48 |
| Numbers of lacunes | 5.2±4.7 | 6.3±5.9 | 0.58 |
| Number of CMBs‡ | 27.4±23.8 | 12.5±17.5 | 0.05 |
| Location of CMBs: none | 0 | 8 | 0.14 |
| Pure deep | 1 | 6 | |
| Pure lobar | 0 | 1 | |
| Mixed | 8 | 13 |
Data were presented by count number (percentage) or mean SD.
*Compared with log-rank test.
†Only 56 patients (12 in ICH, 44 in IS group) had available MRI.
‡Only 37 patients (9 in ICH, 28 in IS group) had available CMBs imaging.
CADASIL, cerebral autosomal-dominant arteriopathy with subcortical infarct and leukoencephalopathy; CMBs, cerebral microbleeds; ICH, intracerebral haemorrhage; IS, ischaemic stroke; WMH, white matter hyperintensity.