Table 3

Statistically significant associations between tissue-specific total sodium concentrations and clinical measures

Clinical measure	All patients (n=96)					Patients with MS (n=78)
Clinical measure	TSC	β	95% CI	p	R ²	TSC	β	95% CI	p	R ²
EDSS	CGM	0.174	0.061 to 0.287	0.003	0.26	CGM T1-hypointense lesions	0.128 0.020	0.010 to 0.246 0.000 to 0.041 (0.002 to 0.037*)	0.035 0.055 (0.023*)	0.25
Walking speed	CGM	−0.006	–0.010 to 0.002	0.003	0.23	CGM T1-hypointense lesions	–0.005 –0.001	–0.009 to 0.001 –0.002 to 0.0005	0.023 0.032	0.24
z 9HPT	CGM	−0.096	–0.148 to 0.051	0.001	0.23	CGM T1-hypointense lesions	–0.091 –0.014	–0.152 to 0.030 –0.025 to 0.004	0.004 0.008	0.32
z PASAT	CGM	−0.105	–0.177 to 0.032	0.005	0.29	CGM	−0.101	–0.180 to 0.023	0.012	0.29
z SDMT	CGM	−0.156	–0.246 to 0.066	0.001	0.31	CGM	−0.143	–0.240 to 0.046	0.005	0.31
z Brixton test	CGM	−0.067	–0.120 to 0.014	0.014	0.36	CGM	−0.066	–0.118 to 0.015	0.013	0.38

*Bootstrap CI and p value.
9HPT, 9 Hole peg test; CGM, cortical grey matter; EDSS, Expanded Disability Status Scale; PASAT, Paced Auditory Serial Addition Test; SDMT, Symbol Digit Modalities Test; TSC, total sodium concentration.