Table 1

Demographic and clinical characteristics of the cohort

Characteristics	Cannabis users (n=71)	Non-cannabis users (n=231)	Non-responders (n=35)	P value
Age at onset, years	20 (14.5–26)	17 (11.8–34)	23 (14.5–35.5)	0.34*
Age, years	33 (24–37)	35 (27–44)	35 (28–46)	0.07*
Male	43 (60.6)	105 (45.5)	24 (68.6)	0.03†
Marital status
Married/common-law	19 (26.8)	97 (42.0)	21 (60.0)	0.03†
Other	52 (73.2)	133 (57.6)	14 (40.0)	0.03†
Education level
High School or below	45 (63.4)	107 (46.3)	15 (42.9)	0.02†
College/university	26 (36.6)	122 (52.8)	20 (57.1)	0.02†
Currently employed	35 (49.3)	126 (54.5)	20 (57.1)	0.58†
Social habits
Alcohol use	36 (50.7)	73 (31.6)	11 (31.4)	<0.001†
Recreational drug use	14 (19.7)	3 (1.3)	1 (2.9)	< 0.001‡
Smokes cigarettes	26 (36.6)	21 (9.1)	9 (25.7)	<0.001†
Current or past psychiatric disorder	33 (46.5)	63 (27.3)	9 (25.7)	0.003†
Epilepsy type
Generalised	34 (47.9)	116 (50.2)	20 (57.1)	0.79†
Focal	37 (52.1)	115 (49.8)	15 (42.9)	0.79†
Duration of epilepsy, years	5 (2–16)	11 (3–22)	7 (2–17)	0.06*
Seizure frequency per month	0.42 (0.08–4.17)	0.08 (0.02–1.08)	0.16 (0.04–1.00)	0.02*
Seizure freedom over the last year	15 (21.1)	70 (30.3)	3 (8.6)	0.21†
Number of current AEDs
Median (IQR); (range)	1 (1–1); (0–4)	1 (1–1); (0–4)	1 (0–1); (0–3)	0.33*
Mean DDD of AEDs	1 (0.67–1.33)	1 (0.67–1.33)	0.92 (0.67–1.00)	0.87*
Epilepsy-specific comorbidity index
Median (IQR); (range)	0 (0–0); (0–3)	0 (0–0); (0–6)	0 (0–0); (0–3)	0.10*
EQ-5D TTO	0.83 (0.69–0.91)	0.87 (0.77–0.95)	0.87 (0.74–0.95)	0.02*

Values are n (%) or median (IQR).
Numbers that do not add up to the appropriate totals or percentages that do not add up to 100% are a result of missing data.
*Mann-Whitney U test of users vs non-users.
†χ² test.
‡Fisher’s exact test.
AED, antiepileptic drug; DDD, defined daily dose; TTO, time trade-off.