AD versus CON | MCI versus CON | |||
CSF KLK8 | Blood KLK8 | CSF KLK8 | Blood KLK8 | |
Cut-off (pg/mL) | 260 | 397 | 342 | 1121 |
Sensitivity (%) (95% CI) | 65.0 (48.3 to 79.4) | 56.1 (45.7 to 66.1) | 91.7 (61.5 to 99.8) | 52.4 (29.8 to 74.3) |
Specificity (%) (95% CI) | 88.6 (73.3 to 96.8) | 69.8 (60.7 to 77.8) | 94.3 (80.8 to 99.3) | 99.2 (95.4 to 100.0) |
Accuracy (%) (95% CI) | 76.0 (64.8 to 85.1) | 63.6 (56.8 to 70.0) | 93.6 (82.5 to 98.7) | 92.1 (86.4 to 96.0) |
OR (95% CI) | 14 (4 to 49) | 2.95 (1.7 to 5.2) | 182 (15 to 2201) | 130 (15 to 1110) |
AD, Alzheimer’s disease;CI, confidence interval; CON, controls; CSF, cerebrospinal fluid; KLK8, Kallikrein-8; MCI, mild cognitive impairment due to AD; OR, odds ratio.