Table 4

Whole-brain voxel-based morphometry (grey matter volume)

Smoothing (FWHM)	FWE-correction level	Peak				Cluster		Correlations
		Peak				Cluster		Memory scores		GM volumes
		t	x (mm)	y (mm)	z (mm)	kE (nvox)	Structure	r	p-corr	GM volumes
4 mm	Peak	5.90	−25	−16	−22	197	L HPC head	0.37	0.225	L HPC head – R body: r=0.61, p-corr=0.002 L – R HPC head: r=0.64, p-corr=0.002 R HPC head – body: r=0.82, p-corr<0.0001
		5.75	37	−27	−11	36	R HPC body	0.10	0.986
		5.57	31	−13	−17	61	R HPC head	0.15	0.986
	Cluster size	5.90	−25	−16	−22	2156	L HPC head/body	0.32	0.424	R-L HPC: r=0.64, p-corr=0.005 R HPC – R Thal: r=0.54, p-corr=0.035 Rest of p-corr>0.15
		5.75	37	−27	−11	2721	R HPC head/body	0.03	>0.999
		5.22	19	−28	5	3085	R Thal	0.34	0.424
		4.74	-2	−39	40	2086	L/R PCC/PrCu	−0.02	>0.999
8 mm	Peak	5.38	32	−15	−16	592	R HPC head/body	0.35	0.267	R-L HPC: r=0.65, p-corr=0.0006 R HPC – R Thal: r=0.55, p-corr=0.006 L HPC – R Thal: r=0.46, p-corr=0.02
		5.19	−27	−15	−20	200	L HPC head/body	0.11	0.599
		4.91	6	−12	7	179	R MD Thal	0.36	0.267
	Cluster size	5.38	32	−15	−16	12 710	L/R HPC/Thal	0.31	0.294	r=0.32, p-corr=0.13
	Cluster size	4.16	-1	−38	38	6606	L/R PCC/PrCu	−0.03	0.900	r=0.32, p-corr=0.13

Contrast: controls > patients; nuisance covariates: age, sex, TIV; voxel dimensions: 1 mm³ ; individual voxel threshold: p<0.001. The average GM volume from each cluster was extracted from each participant, residualised against age, sex, and TIV, and entered in a bivariate correlation analysis with the memory composite score. No correlation was noted with the GM volume of any cluster; hippocampal volume reduction strongly correlated with thalamic volume reduction in patients; p-corr: p values of the bivariate correlations conducted are adjusted for multiple testing using the Holm-Bonferroni sequential correction method, separately for the number of clusters disclosed in each of the four separate VBM analyses conducted.
GM, grey matter; HPC, hippocampus; L/R, left/right; MD, mediodorsal; PCC, posterior cingulate cortex; PrCu, precuneus; TIV, total intracranial volume; Thal, thalamus; VBM, voxel-based morphometry.