Table 3

Association between neurofilament light chain and clinical characteristics or global cognitive scales in patients with SD

Cross-sectionalLongitudinal
N rs P valueN rs P value
Age at CSF collection162−0.0020.98n/an/an/a
Age at onset157−0.060.46n/an/an/a
Disease duration at CSF collection1570.030.68n/an/an/a
MMSE135−0.110.2051−0.29 0.04
Global CDR780.150.1833−0.030.86
CDR-SB650.230.0733−0.010.97
FTD-CDR-SB340.050.79100.330.37
  • For longitudinal analysis, annualised change of the scores was used. P<0.05 are in bold, none survived Bonferroni correction for multiple testing.

  • CDR, global score of clinical dementia rating scale; CDR-SB, clinical dementia rating scale sum of boxes; CSF, cerebrospinal fluid; FTD-CDR, frontotemporal dementia clinical dementia rating scale; MMSE, Mini-Mental State Examination.