Table 3

Volumetry of medial temporal lobe and subcortical structures

Structure		Hemisphere	Mean (z)	SD (z)	vs 0		n atrophic	Correlation with memory composite score
					t	p-corr		Correlation with memory composite score
					t	p-corr		R	p-corr
HPC	Head	R	−1.71	1.79	−4.68	0.003	14	−0.035	>0.999
	Head	L	−1.71	1.52	−5.53	0.0003	16	0.181
	Body	R	−0.95	1.07	−4.37	0.006	7	0.043	>0.999
	Body	L	−0.81	1.47	−2.69	0.25	8	n/a
	Tail	R	−0.67	1.56	−2.11	0.83	9
	Tail	L	−0.58	1.51	−1.87	>0.999	7
ERC		R	−0.70	1.08	−3.18	0.09	3
ERC		L	−0.77	1.35	−2.81	0.21	8
PRC		R	−0.43	1.25	−1.66	>0.999	1
PRC		L	−0.21	1.13	−0.90	>0.999	2
PHC		R	−0.50	0.89	−2.76	0.23	2
PHC		L	−0.36	1.20	−1.46	>0.999	5
AMG		R	0.06	1.36	0.21	>0.999	3
AMG		L	−0.14	1.72	−0.39	>0.999	4
TPC		R	0.20	1.13	0.87	>0.999	1
TPC		L	0.30	1.01	1.46	>0.999	0
Thalamus		R	−0.75	0.95	−3.86	0.02	5	0.187	>0.999
Thalamus		L	−0.89	1.04	−4.20	0.008	6	0.173	>0.999
Caudate nucleus		R	−0.03	1.00	−0.14	>0.999	1	n/a
Caudate nucleus		L	−0.02	1.36	−0.06	>0.999	2
Nucleus accumbens		R	−0.16	0.87	−0.88	>0.999	1
Nucleus accumbens		L	−0.40	1.30	−1.51	>0.999	4
Pallidum		R	−0.28	1.10	−1.25	>0.999	3
Pallidum		L	−0.22	1.32	−0.81	>0.999	3
Putamen		R	−0.23	1.10	−1.01	>0.999	3
Putamen		L	−0.38	0.94	−2.00	0.98	3
Brainstem			−0.33	1.08	−1.49	>0.999	3

For controls and patients, MTL structures (hippocampal head, body, tail, amygdala, entorhinal, parahippocampal, perirhinal, temporopolar cortex) were manually segmented,and other subcortical structures (thalamus, pallidum, putamen, brainstem, nucleus accumbens, and caudate nucleus) were automatically segmented (FSL FIRST). All volumes were TIV-corrected and expressed as z-scores, based on the mean and SD of patients’ individually age-matched controls (± 10 years of age). Comparisons are hence conducted as one-sample t-tests versus 0 (control mean); p-corr: two-tailed, adjusted with Holm-Bonferroni sequential correction for multiple testing. Bold: p-corr <0.05; r: Pearson’s correlation coefficient; of the volumes that showed reduction in patients relative to controls, none showed correlation with composite memory scores. No correlation was found with total/left/right hippocampal atrophy at uncorrected levels (all ps, p>0.88); ‘n atrophic’: number of patients whose volumes fall below −1.5 SD from those of their age-matched healthy controls.
AMG, amygdala; ERC, entorhinal cortex; HPC, hippocampus; MTL, medial temporal lobe; PHC, parahippocampal cortex; PRC, perirhinal cortex; TIV, total intracranial volume; TPC, temporopolar cortex.