Table 3

Volumetry of medial temporal lobe and subcortical structures

StructureHemisphereMean (z)SD (z)vs 0n atrophicCorrelation with memory composite score
tp-corr
Rp-corr
HPC Head R 1.71 1.79 4.68 0.003 14−0.035>0.999
L 1.71 1.52 5.53 0.0003 160.181>0.999
Body R 0.95 1.07 4.37 0.006 70.043>0.999
L−0.811.47−2.690.258n/a
TailR−0.671.56−2.110.839
L−0.581.51−1.87>0.9997
ERCR−0.701.08−3.180.093
L−0.771.35−2.810.218
PRCR−0.431.25−1.66>0.9991
L−0.211.13−0.90>0.9992
PHCR−0.500.89−2.760.232
L−0.361.20−1.46>0.9995
AMGR0.061.360.21>0.9993
L−0.141.72−0.39>0.9994
TPCR0.201.130.87>0.9991
L0.301.011.46>0.9990
Thalamus R 0.75 0.95 3.86 0.02 50.187>0.999
L 0.89 1.04 4.20 0.008 60.173>0.999
Caudate nucleusR−0.031.00−0.14>0.9991n/a
L−0.021.36−0.06>0.9992
Nucleus accumbensR−0.160.87−0.88>0.9991
L−0.401.30−1.51>0.9994
PallidumR−0.281.10−1.25>0.9993
L−0.221.32−0.81>0.9993
PutamenR−0.231.10−1.01>0.9993
L−0.380.94−2.000.983
Brainstem−0.331.08−1.49>0.9993
  • For controls and patients, MTL structures (hippocampal head, body, tail, amygdala, entorhinal, parahippocampal, perirhinal, temporopolar cortex) were manually segmented,and other subcortical structures (thalamus, pallidum, putamen, brainstem, nucleus accumbens, and caudate nucleus) were automatically segmented (FSL FIRST). All volumes were TIV-corrected and expressed as z-scores, based on the mean and SD of patients’ individually age-matched controls (± 10 years of age). Comparisons are hence conducted as one-sample t-tests versus 0 (control mean); p-corr: two-tailed, adjusted with Holm-Bonferroni sequential correction for multiple testing. Bold: p-corr <0.05; r: Pearson’s correlation coefficient; of the volumes that showed reduction in patients relative to controls, none showed correlation with composite memory scores. No correlation was found with total/left/right hippocampal atrophy at uncorrected levels (all ps, p>0.88); ‘n atrophic’: number of patients whose volumes fall below −1.5 SD from those of their age-matched healthy controls.

  • AMG, amygdala; ERC, entorhinal cortex; HPC, hippocampus; MTL, medial temporal lobe; PHC, parahippocampal cortex; PRC, perirhinal cortex; TIV, total intracranial volume; TPC, temporopolar cortex.