Associations between neurofilament light chain and neuropsychological test scores
| Test | Correlation | Multivariate regression | |||
| N | rs | P value | β | P value | |
| BNT | 89 | −0.32 | 0.002* | −0.34 | 0.002* |
| Categorical fluency | 110 | −0.17 | 0.08 | −0.14 | 0.14 |
| Letter fluency | 66 | −0.03 | 0.83 | −0.14† | 0.28 |
| Digit span | 107 | 0.07 | 0.47 | 0.04 | 0.71 |
| TMT-A | 84 | −0.23 | 0.04 | −0.20† | 0.07 |
| TMT-B | 78 | −0.30 | 0.007 | −0.19† | 0.09 |
| SCWT interference ratio | 52 | 0.12 | 0.39 | 0.08‡ | 0.57 |
| Word list immediate recall | 60 | −0.17 | 0.20 | −0.22§ | 0.08 |
| Word list delayed recall | 60 | −0.23 | 0.07 | −0.24§ | 0.08 |
| Clock drawing test | 30 | 0.23 | 0.23 | 0.21† | 0.30 |
| Rey figure copy | 50 | −0.05 | 0.71 | 0.04† | 0.76 |
| Rey figure delayed recall | 44 | −0.17 | 0.27 | −0.24† | 0.10 |
Multivariate regression is corrected for age, gender and laboratory. P<0.05 are in bold.
*Survived Bonferroni correction for multiple testing (p<0.004).
†Not corrected for laboratory as all samples were analysed in the same laboratory for these tests.
‡After additional correction for version seconds to complete versus number correct: β=0.15, p=0.27.
§Similar results with additional correction for test version.
BNT, Boston Naming Test; SCWT, Stroop Color-Word Task; TMT, Trail-making Test.