Random sequence generation (selection bias) | Unclear | Low | Low | Low | Unclear | Unclear | Low | Low | Low | Low | Low | Low |
Allocation concealment (selection bias) | Unclear | Low | Low | Unclear | Unclear | Unclear | Unclear | Low | Low | Low | Unclear | Low |
Blinding of assessors (performance bias) | Unclear | Low | Low | Unclear | Unclear | Unclear | Unclear | Low | Low | Low | Unclear | Low |
Blinding of outcome assessment (detection bias) (patient reported outcomes) | High | Low | Low | Unclear | Unclear | Unclear | Unclear | Low | Low | Low | Unclear | Low |
Incomplete outcome data addressed (attrition bias) | Unclear | Low | Low | High | High | Unclear | Unclear | Unclear | Low | Low | Unclear | Low |
Selective outcome reporting (reporting bias) | High | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low | Low |
Other sources of bias (ie, baseline bias) | Unclear | Low | Low | High | Unclear | High | High | Low | Low | Low | Low | Low |
Overall risk of bias | High | Low | Low | High | High | High | High | Unclear | Low | Low | Unclear | Low |