Region of interest | Cross-sectional (n=87) | Longitudinal (n=32) | ||||||
Correlation | Multivariate regression | Correlation | Multivariate regression | |||||
rs | P value | β | P value | rs | P value | β | P value | |
Temporal pole† | −0.13 | 0.24 | −0.13 | 0.27 | −0.11 | 0.57 | −0.11 | 0.63 |
Medial and inferior temporal gyri | −0.28 | 0.009 | −0.21 | 0.06 | 0.03 | 0.88 | −0.29 | 0.16 |
Superior temporal gyrus, central part | −0.17 | 0.11 | −0.16 | 0.16 | −0.01 | 0.94 | −0.07 | 0.72 |
Fusiform gyrus | −0.16 | 0.14 | −0.18 | 0.12 | −0.33 | 0.07 | −0.34 | 0.08 |
Parahippocampal gyrus | −0.31 | 0.004‡ | −0.33 | 0.003‡ | 0.08 | 0.67 | −0.04 | 0.85 |
Hippocampus | −0.20 | 0.07 | −0.20 | 0.08 | 0.02 | 0.93 | 0.06 | 0.80 |
Amygdala | −0.18 | 0.09 | −0.19 | 0.09 | 0.12 | 0.54 | 0.08 | 0.69 |
Insula | −0.19 | 0.07 | −0.17 | 0.13 | −0.09 | 0.62 | 0.04 | 0.82 |
Orbitofrontal cortex§ | −0.05 | 0.62 | −0.05 | 0.67 | 0.10 | 0.59 | 0.17 | 0.40 |
Inferior frontal gyrus | −0.03 | 0.78 | 0.04 | 0.76 | 0.09 | 0.61 | 0.03 | 0.87 |
Anterior cingulate gyrus¶ | −0.02 | 0.89 | 0.07 | 0.56 | 0.00 | 1.00 | −0.02 | 0.91 |
Association of neurofilament light chain with gray matter regions of the dominant side on cross-sectional scanning and with change in volume between follow-up and baseline scan.
For cross-sectional associations, intracranial volume-corrected volumes were used; for longitudinal associations, the change of volume per year was used. Multivariate regression was corrected for age, gender, laboratory and scanner (the latter only for cross-sectional scans); P<0.05 are in bold.
*Of the patients with a usable baseline MRI scan (n=87), 65 were left-dominant while 22 were right-dominant, which indicated a strong temporal asymmetry (mean ratio temporal atrophy of 0.76 (±0.08).
†Combination of the medial anterior temporal lobe, lateral anterior temporal lobe and the anterior part of the superior temporal gyrus.
‡Survived Bonferroni correction for multiple testing (p<0.0045).
§Combination of the anterior, medial, lateral and posterior orbital gyri.
¶Combination of the supragenual, subgenual and presubgenual part of the anterior cingulate gyrus.