Table 4

Associations between neurofilament light chain and grey matter regions of interest of the dominant side*

Region of interestCross-sectional (n=87)Longitudinal (n=32)
CorrelationMultivariate regressionCorrelationMultivariate regression
rs P valueβP valuers P valueβP value
Temporal pole†−0.130.24−0.130.27−0.110.57−0.110.63
Medial and inferior temporal gyri−0.28 0.009 −0.210.060.030.88−0.290.16
Superior temporal gyrus, central part−0.170.11−0.160.16−0.010.94−0.070.72
Fusiform gyrus−0.160.14−0.180.12−0.330.07−0.340.08
Parahippocampal gyrus−0.31 0.004‡ −0.33 0.003‡ 0.080.67−0.040.85
Hippocampus−0.200.07−0.200.080.020.930.060.80
Amygdala−0.180.09−0.190.090.120.540.080.69
Insula−0.190.07−0.170.13−0.090.620.040.82
Orbitofrontal cortex§−0.050.62−0.050.670.100.590.170.40
Inferior frontal gyrus−0.030.780.040.760.090.610.030.87
Anterior cingulate gyrus¶−0.020.890.070.560.001.00−0.020.91
  • Association of neurofilament light chain with gray matter regions of the dominant side on cross-sectional scanning and with change in volume between follow-up and baseline scan.

  • For cross-sectional associations, intracranial volume-corrected volumes were used; for longitudinal associations, the change of volume per year was used. Multivariate regression was corrected for age, gender, laboratory and scanner (the latter only for cross-sectional scans); P<0.05 are in bold.

  • *Of the patients with a usable baseline MRI scan (n=87), 65 were left-dominant while 22 were right-dominant, which indicated a strong temporal asymmetry (mean ratio temporal atrophy of 0.76 (±0.08).

  • †Combination of the medial anterior temporal lobe, lateral anterior temporal lobe and the anterior part of the superior temporal gyrus.

  • ‡Survived Bonferroni correction for multiple testing (p<0.0045).

  • §Combination of the anterior, medial, lateral and posterior orbital gyri.

  • ¶Combination of the supragenual, subgenual and presubgenual part of the anterior cingulate gyrus.