Patients with SD, n=162 | Controls, n=65 | P value | |
Sex, n male (%) | 75 (46%) | 32 (49%) | 0.69 |
Age at CSF collection, years | 64 (58–68) | 65 (60–70) | 0.43 |
Age at onset, years | 60 (54–65)* | n/a | n/a |
Age at death, years | 69 (65–74)† | n/a | n/a |
MMSE score | 25 (21–28)‡ | n/a | n/a |
CDR-SB score | 3.5 (2.5–4.8)§ | n/a | n/a |
FTD-CDR-SB score | 4.0 (2.0–6.0)¶ | n/a | n/a |
CSF NfL, pg/mL | 2326 (1628–3593) | 577 (446–766) | <0.001 |
Isolated decreased abeta, n (%) | 8 (5%) | n/a | n/a |
Isolated increased p-tau and/or t-tau, n (%) | 61 (38%) | n/a | n/a |
MRI available at baseline (at follow-up), n | 87 (32) | n/a | n/a |
Continuous variables are presented as medians (IQR).
*Unknown in five patients.
†30 patients were known to be deceased at time of data analysis.
‡Available in 135 patients.
§Available in 65 patients.
¶Available in 34 patients.
CDR-SB, Clinical Dementia Rating scale sum of boxes; CSF, cerebrospinal fluid; FTD-CDR-SB, frontotemporal dementia CDR-SB; MMSE, Mini-Mental State Examination; NfL, neurofilament light chain; SD, semantic dementia; abeta, amyloid-β1-42; p-tau and/or t-tau, phospho-tau and/or total-tau.