Characteristic | Euro-MOTOR total | Ireland | Italy-Apulia | Italy-Lombardy | Italy-Piedmont & Val d’Aosta | The Netherlands | ||||||
Case n=1410 | Control n=2616 | Case n=164 | Control n=326 | Case n=124 | Control n=104 | Case n=166 | Control n=131 | Case n=250 | Control n=213 | Case n=706 | Control n=1842 | |
Sex, n (%) | ||||||||||||
Men | 821 (58) | 1522 (58) | 98 (60) | 197 (60) | 72 (58) | 54 (52) | 91 (55) | 60 (46) | 133 (53) | 108 (51) | 427 (60) | 1103 (60) |
Women | 589 (42) | 1094 (42) | 66 (40) | 129 (40) | 52 (42) | 50 (48) | 75 (45) | 71 (54) | 117 (47) | 105 (49) | 279 (40) | 739 (40) |
Age at survey (years), n (%) | ||||||||||||
<50 | 139 (9.9) | 245 (9.4) | 16 (9.8) | 32 (9.8) | 11 (8.9) | 17 (16) | 13 (7.8) | 14 (11) | 28 (11) | 29 (14) | 71 (10) | 153 (8.3) |
50 to <60 | 260 (18) | 555 (21) | 31 (19) | 56 (17) | 26 (21) | 23 (22) | 31 (19) | 31 (24) | 37 (15) | 45 (21) | 135 (19) | 400 (22) |
60 to <70 | 561 (40) | 1082 (41) | 62 (38) | 121 (37) | 51 (41) | 43 (41) | 62 (37) | 44 (34) | 84 (34) | 70 (33) | 302 (43) | 804 (44) |
70 to <80 | 383 (27) | 639 (24) | 42 (26) | 96 (29) | 31 (25) | 17 (16) | 51 (31) | 32 (24) | 88 (35) | 55 (26) | 171 (24) | 439 (24) |
80+ | 67 (4.8) | 95 (3.6) | 13 (7.9) | 21 (6.4) | 5 (4.0) | 4 (3.9) | 9 (5.4) | 10 (7.6) | 13 (5.2) | 14 (6.6) | 27 (3.8) | 46 (2.5) |
Education*, n (%) | ||||||||||||
ISCED 0–4 | 1158 (82) | 1931 (74) | 138 (84) | 255 (78) | 115 (93) | 88 (85) | 151 (91) | 84 (64) | 234 (94) | 186 (87) | 521 (74) | 1318 (72) |
ISCED 5–8 | 250 (18) | 685 (26) | 26 (16) | 71 (22) | 9 (7.3) | 16 (15) | 15 (9.0) | 47 (36) | 16 (6.4) | 27 (13) | 185 (26) | 524 (28) |
Alcohol drinking, n (%) | ||||||||||||
Never | 320 (23) | 387 (15) | 28 (17) | 62 (19) | 46 (37) | 56 (54) | 54 (33) | 49 (37) | 92 (37) | 66 (31) | 100 (14) | 154 (8.4) |
Former | 114 (8.1) | 112 (4.3) | 18 (11) | 17 (5.2) | 10 (8.1) | 3 (2.9) | 12 (7.2) | 4 (3.1) | 17 (6.8) | 15 (7.0) | 57 (8.1) | 73 (4.0) |
Current | 976 (69) | 2117 (81) | 118 (72) | 247 (76) | 68 (55) | 45 (43) | 100 (60) | 78 (60) | 141 (56) | 132 (62) | 549 (78) | 1615 (88) |
Disease site of onset, n (%) | ||||||||||||
Bulbar | 461 (33) | – | 40 (24) | – | 34 (27) | – | 49 (30) | – | 93 (37) | – | 245 (35) | – |
Spinal | 934 (66) | – | 124 (76) | – | 88 (71) | – | 117 (70) | – | 157 (63) | – | 448 (63) | – |
Unknown/generalised | 15 (1.1) | – | 0 | – | 2 (1.6) | – | 0 | – | 0 | – | 13 (1.8) | – |
C9orf72 variant†, n (%) | ||||||||||||
Wild type | 818 (58) | – | 147 (90) | – | 0 | – | 71 (43) | – | 0 | – | 600 (85) | – |
Repeat expansion | 84 (6.0) | – | 13 (7.9) | – | 2 (1.6) | – | 6 (3.6) | – | 0 | – | 63 (8.9) | – |
Unknown | 508 (36) | – | 4 (2.4) | – | 122 (98) | – | 89 (54) | – | 250 (100) | – | 43 (6.1) | – |
Smoking status, n (%) | ||||||||||||
Never | 562 (40) | 1016 (39) | 74 (45) | 163 (50) | 54 (44) | 52 (50) | 74 (45) | 70 (53) | 132 (53) | 107 (50) | 228 (32) | 624 (34) |
Former | 561 (40) | 1223 (47) | 57 (35) | 128 (39) | 43 (35) | 22 (21) | 61 (37) | 42 (32) | 72 (29) | 69 (32) | 328 (46) | 962 (52) |
Current | 287 (20) | 377 (14) | 33 (20) | 35 (11) | 27 (22) | 30 (29) | 31 (19) | 19 (45) | 46 (18) | 37 (17) | 150 (21) | 256 (14) |
Intensity, median (cig/day)† | 14.2 | 12.0 | 15.0 | 20.0 | 15.0 | 11.1 | 15.2 | 15.0 | 17.1 | 15.4 | 11.0 | 10.0 |
Duration, median (years)† | 27.0 | 23.0 | 25.5 | 24.0 | 27.5 | 25.0 | 32.5 | 32.0 | 31.0 | 27.0 | 26.0 | 22.0 |
Packyears, median† | 17.3 | 13.6 | 19.8 | 22.0 | 20.8 | 13.0 | 18.8 | 24.0 | 20.3 | 19.0 | 15.1 | 12.3 |
TSQ, median (years)‡,§ | 22.0 | 25.0 | 24.0 | 25.0 | 20.0 | 15.0 | 21.0 | 22.0 | 17.0 | 21.0 | 24.0 | 26.0 |
Age at start, median (years)† | 17.0 | 16.0 | 16.0 | 17.0 | 16.5 | 17.0 | 18.0 | 19.0 | 18.0 | 18.0 | 16.0 | 16.0 |
*ISCED, International Standard Classification of Education.15
†Among smokers.
‡Among former smokers.
§TSQ, time-since-quitting.