Table 4

UPSIT at baseline and 6-year change in clinical markers in pooled Het GBA and GD groups

UPSIT>23UPSIT≤23P value (FP test)*
UPSIT−0.7±0.5 (33)−5.0±3.1 (4)0.020†
UMSARS1.4±0.2 (40)2.8±1.0 (4)0.080
RBDsq2.6±0.5 (32)1.7±0.3 (3)0.727
MoCA1.5±0.4 (40)−2±1.7 (3)0.022†
MDS-UPDRS III1.9±0.8 (40)10.0±5.3 (4)0.010†
BDI4.6±1.3 (29)17±6.1 (3)0.012†
  • Difference between 6-year follow-up and baseline measurements. Data are reported as mean±SE (number of subjects).

  • *Non-parametric two-sample Fisher-Pitman permutation test. The statistic used is the difference in means of two samples. A false discovery rate of 5% was set using the Benjamini-Hochberg procedure.

  • †Significant result.

  • BDI, Beck Depression Inventory; GD, patients with Gaucher disease; MDS-UPDRS III, Movement Disorders Society Unified Parkinson’s Disease Rating Scale motor subscale; MoCA, Montreal Cognitive Assessment; RBDsq, REM Sleep Behavior Disorder screening questionnaire; UMSARS, Unified Multiple System Atrophy Rating Scale; UPSIT, University of Pennsylvania Smell Identification Test.