Table 1

Baseline cohort demographics and characteristics

	Healthy controls (n=177) Mean± SD	PD-NC (n=205) Mean± SD	PD-UC (n=103) Mean± SD	PD-BC (n=89) Mean± SD
Age, years	60.95±11.20	60.98±10.16	60.63±9.76	64.46±8.13*
Male/Female	116/61	131/74	68/35	59/30
Years of education	16.11±2.93	15.75±2.92	15.20±3.15	15.42±2.97
Duration of symptoms, years		1.53±2.40	1.55±1.63	1.30±1.50
Duration since diagnosis, years		0.14±0.40	0.20±0.53	0.20±0.45
Stage of disease (H&Y)		1.46±0.50	1.56±0.50	1.56±0.50
Total MDS-UPDRS Part III (motor)		19.47±9.16	21.11 ± 8.69	21.38±8.89
MoCA examination	28.38±1.23	27.40±2.19*	27.07±2.63*	27.30±2.31*
GDS score	1.30±2.14	2.16±2.45*	2.50±2.43*	2.61±2.61*
GDS≥5	11 (6.2%)	23 (11.2%)*	17 (16.5%)*	16 (18.0%)*
RBDSQ	2.97±2.38	4.35±2.86*	4.29±2.50*	5.02±3.18*
Gait Index	–	0.32±0.80	0.32±0.57	0.40±0.69

Significant difference compared with healthy controls (*p<0.05).
GDS, Geriatric Depression Score; H&Y, Hoehn & Yahr scale; MDS-UPDRS, Movement Disorder Society Unified Parkinson’s Disease Rating Scale; MoCA, Montreal Cognitive Assessment; PD-BC, bilaterally reduced caudate binding;PD-NC, no reduced ¹²³I-FP-CIT binding in either caudate; PD-UC, reduced ¹²³I-FP-CIT binding in one caudate only; RBD, REM sleep behaviour disorder; RBDSQ, RBD Screening Questionnaire.