Morphometric assessments differentiating PSP and its variants from PD and HC with AUC >0.6
| PSP-RS vs PD | MRPI (13.89) | MRPI 2.0 (3.18) | P/M (4.97) | P/M 2.0 (1.17) | MCP/SCP (2.63) |
| Sensitivity | 86.8 | 89.5 | 94.4 | 94.7 | 67.7 |
| Specificity | 91.4 | 85.7 | 88.6 | 85.7 | 74.3 |
| PPV | 91.7 | 87.2 | 89.5 | 87.8 | 71.9 |
| NPV | 86.5 | 88.2 | 93.9 | 93.8 | 68.4 |
| Diagnostic accuracy | 89 | 87.6 | 91.5 | 93.1 | 67.7 |
| PSP-RS vs HC | MRPI (11.58) | MRPI 2.0 (2.59) | P/M (4.77) | P/M 2.0 (1.16) | MCP/SCP (2.5) |
| Sensitivity | 91.4 | 94.7 | 97.2 | 94.7 | 80 |
| Specificity | 89.2 | 92.1 | 91.2 | 94.7 | 78.8 |
| PPV | 88.9 | 93.2 | 92.1 | 94.7 | 71.8 |
| NPV | 91.7 | 94.6 | 97.1 | 94.7 | 78.8 |
| Diagnostic accuracy | 90.2 | 93.4 | 94.5 | 97.3 | 75 |
| PSP-P vs PD | MRPI (11.7) | MRPI 2.0 (2.58) | P/M (4.72) | P/M 2.0 (1.08) | MCP/SCP |
| Sensitivity | 65 | 76.2 | 71.4 | 66.7 | NS |
| Specificity | 74.3 | 65.7 | 77.1 | 68.6 | NS |
| PPV | 59.1 | 57.1 | 65.2 | 56 | NS |
| NPV | 78.8 | 82.1 | 81.8 | 77.4 | NS |
| Diagnostic accuracy | 70.9 | 69.6 | 75 | 67.8 | NS |
| PSP-P vs HC | MRPI (10.27) | MRPI 2.0 (2.2) | P/M (4.59) | P/M 2.0 (0.97) | MCP/SCP (2.44) |
| Sensitivity | 80 | 85.7 | 81 | 85.7 | 75 |
| Specificity | 75.6 | 84.2 | 86.5 | 89.5 | 64.9 |
| PPV | 64 | 75 | 77.3 | 81.8 | 53.6 |
| NPV | 87.5 | 91.4 | 88.9 | 91.9 | 82.8 |
| Diagnostic accuracy | 77.1 | 84.7 | 84.4 | 88.1 | 68.4 |
| vPSP vs PD | MRPI (11.34) | MRPI 2.0 (2.47) | P/M (4.65) | P/M 2.0 (1.05) | MCP/SCP (2.63) |
| Sensitivity | 84.2 | 84.2 | 84.2 | 84.2 | 63.2 |
| Specificity | 68.6 | 62.9 | 68.6 | 62.9 | 74.3 |
| PPV | 59.3 | 55.2 | 59.3 | 55.2 | 57.1 |
| NPV | 88.9 | 88 | 88.9 | 88 | 78.8 |
| Diagnostic accuracy | 74 | 70.3 | 74 | 70.3 | 70.3 |
| vPSP vs HC | MRPI (11.32) | MRPI 2.0 (2.3) | P/M (4.67) | P/M 2.0 (0.99) | MCP/SCP (2.46) |
| Sensitivity | 84.2 | 89.5 | 84.2 | 89.5 | 68.4 |
| Specificity | 86.5 | 89.5 | 91.9 | 89.5 | 64.9 |
| PPV | 76.2 | 81 | 84.2 | 81 | 50 |
| NPV | 91.4 | 94.4 | 91.9 | 94.4 | 80 |
| Diagnostic accuracy | 85.7 | 89.4 | 89.2 | 89.4 | 66 |
The best threshold for classification for each morphometric assessment is reported in brackets.
AUC, area under a receiver operating characteristic curve; HC, healthy controls; MCP/SCP, middle cerebellar peduncles to superior cerebellar peduncles ratio; MRPI 2.0, MR Parkinsonism Index version 2.0; MRPI, MR Parkinsonism Index; NPV, negative predictive value; NS, not significant; PD, Parkinson’s disease; P/M, pons area to midbrain area ratio; P/M 2.0, pons area to midbrain area ratio version 2.0; PPV, positive predictive value; PSP, progressive supranuclear palsy; PSP-P, progressive supranuclear palsy with parkinsonism; PSP-RS, progressive supranuclear palsy with Richardson’s syndrome; vPSP, other variant syndromes of progressive supranuclear palsy.