Median score (IQR) at start open-label phase | Median score (IQR) end of follow-up | P value* | |
CGI-severity investigator | 3.0 (2.0; 4.0) | 2.0 (1.0; 4.0) | 0.005 |
CGI-severity patient | 4.0 (4.0; 5.75) | 4.0 (2.0; 5.0) | 0.044 |
VAS-disease burden patient | 48.0 (20.3; 71.8) | 28.0 (3.0; 62.0) | 0.042 |
PMDRS-motor symptoms | 10.0 (5.0; 21.0) | 9.0 (3.0; 17.0) | 0.010 |
SF-36-Physical component† | 34.4 (25.1; 48.3) | 40.2 (27.4; 53.6) | 0.058 |
SF-36-Mental component† | 52.5 (41.2; 56.9) | 50.0 (37.9; 55.7) | 0.751 |
ALDS-disability† | 87.8 (79.2; 89.5) | 89.1 (83.5; 89.5) | 0.790 |
BDI-Depressive symptoms† | 9.0 (4.0; 12.0) | 6.0 (3.0; 13.5) | 0.370 |
MADRS-Depressive symptoms | 12.0 (15.0; 18.8) | 10.0 (4.0; 18.0) | 0.205 |
BAI-Anxiety symptoms† | 11.0 (3.5; 17.0) | 7.0 (4.0; 16.0) | 0.127 |
LSAS-Social anxiety† | 10.0 (4.0; 21.5) | 10.0 (2.0; 16.5) | 0.446 |
OCI-Obsessive-Compulsive symptoms† | 4.0 (1.0; 7.0) | 3.0 (1.5; 5.0) | 0.028 |
Bold figures indicate P values< 0.05.
*Wilcoxon signed-rank test for paired data.
†Data of n=41 patients.
ALDS, AMC Linear Disability Score; BAI, Beck Anxiety Inventory; BDI, Beck Depression Inventory; CGI, Clinical Global Impression; IQR, Interquartile range; LSAS, Liebowitz Social Anxiety Scale; MADRS, Montgomery Asberg Depression Rating Scale; OCI, Obsessive Compulsive Inventory; PMDRS, Psychogenic Movement Disorder Rating Scale; SF-36, Short Form 36; VAS, Visual Analogue Scale.