Overall (n=1082) | Psychosis* (n=190) | No psychosis (n=892) | Statistical comparison† | ||
OR | P value | ||||
Demographics | |||||
Age | 51.64 (11.75) | 52.15 (11.47) | 51.54 (11.82) | 1.00 | 0.650 |
Sex (female) | 572 (52.9%) | 101 (53.2%) | 471 (52.8%) | 1.00 | 0.982 |
Education (tertiary) | 444 (41.1%) | 66 (35.1%) | 378 (42.4%) | 0.74 | 0.075 |
CAG | 44.30 (4.12) | 44.05 (3.91) | 44.35 (4.16) | 0.98 | 0.370 |
Time since diagnosis | 7.95 (6.22) | 9.19 (6.90) | 7.57 (5.96) | 1.03 | 0.191 |
Function | |||||
Total functional capacity | 8.23 (3.40) | 6.98 (3.71) | 8.50 (3.28) | 0.87 | <0.001 |
Independence scale | 18.89 (6.00) | 73.37 (17.59) | 81.15 (15.74) | 0.97 | <0.001 |
Cognition | |||||
MMSE | 25.12 (4.45) | 24.19 (4.96) | 25.32 (4.31) | 0.95 | 0.007 |
Behavioural symptoms | |||||
Behavioural total score‡ | 13.31 (14.79) | 20.11 (17.40) | 11.87 (13.77) | 1.03 | <0.001 |
Motor symptoms | |||||
Total motor score | 38.64 (18.76) | 40.24 (19.75) | 38.30 (18.54) | 1.00 | 0.425 |
Chorea | 9.99 (5.14) | 9.13 (5.29) | 10.18 (5.09) | 0.96 | 0.005 |
Dystonia | 3.46 (3.81) | 3.42 (4.03) | 3.46 (3.76) | 0.99 | 0.581 |
Rigidity | 1.36 (1.59) | 1.53 (1.68) | 1.32 (1.56) | 1.07 | 0.168 |
Balance | 3.90 (2.76) | 4.29 (3.03) | 3.82 (2.70) | 1.06 | 0.073 |
Medications | |||||
Antipsychotics | 376 (34.8%) | 108 (56.8%) | 268 (30.0%) | 1.70 | 0.050 |
Tetrabenazine | 58 (5.4%) | 10 (5.3%) | 48 (5.4%) | 0.75 | 0.581 |
Function, motor and neuropsychiatric symptoms measured using Unified Huntington Disease Rating Scale. Summary figures are means for continuous variables or numbers for categorical variables. Numbers in brackets indicate SD for continuous variables and percentages for categorical variables.
*Psychosis includes all participants who experienced psychotic symptoms in the past or during the study.
†Statistical comparison between patients with psychosis and patients without psychosis, adjusted for time since clinical diagnosis.
‡Excluding delusions and hallucinations.
CAG, number of cytosine–adenine–guanine repeats; MMSE, Mini-Mental State Examination.