Cognitive test | Groups | Cases (n) | Treatment time* | Repeated measures† | ||||
Baseline | 6 months | 12 months | Interaction effect, P | Time effect, P | Group effect, P | |||
FSIQ | Intervention | 105 | 91.40±8.46 | 91.45±7.62 | 92.26±7.94 | <0.001 | <0.001 | <0.001 |
Control | 105 | 88.43±9.34 | 85.60±7.57 | 82.45±8.44 | ||||
Information | Intervention | 105 | 6.02±1.64 | 6.88±1.56 | 7.87±1.79 | <0.001 | <0.001 | <0.001 |
Control | 105 | 5.70±1.80 | 5.73±1.73 | 4.66±1.80 | ||||
Comprehension | Intervention | 105 | 4.40±1.86 | 3.85±1.95 | 3.27±1.69 | 0.051 | <0.001 | 0.253 |
Control | 105 | 3.99±2.06 | 3.62±2.13 | 2.60±1.85 | ||||
Arithmetic | Intervention | 105 | 7.36±1.90 | 6.71±1.73 | 4.72±2.07 | 0.027 | <0.001 | <0.001 |
Control | 105 | 6.89±2.07 | 5.91±1.93 | 3.99±2.04 | ||||
similarities | Intervention | 105 | 7.43±1.49 | 7.07±1.50 | 6.66±1.39 | 0.398 | <0.001 | 0.703 |
Control | 105 | 7.13±1.68 | 6.89±1.48 | 6.33±1.35 | ||||
Digit span | Intervention | 105 | 3.83±1.27 | 5.73±1.55 | 5.33±1.82 | <0.001 | <0.001 | <0.001 |
Control | 105 | 3.68±1.55 | 2.53±1.16 | 2.10±1.03 | ||||
Vocabulary | Intervention | 105 | 6.26±1.41 | 6.48±1.32 | 7.06±1.39 | <0.001 | 0.145 | <0.001 |
Control | 105 | 6.06±1.90 | 5.98±1.86 | 5.31±1.84 | ||||
Digit symbol | Intervention | 105 | 8.72±2.01 | 8.38±1.83 | 8.93±1.98 | 0.620 | <0.001 | 0.848 |
Control | 105 | 7.87±2.59 | 7.66±2.28 | 8.15±2.49 | ||||
Picture completion | Intervention | 105 | 10.42±2.73 | 8.61±2.73 | 9.26±2.71 | 0.547 | <0.001 | 0.846 |
Control | 105 | 9.23±3.33 | 7.71±3.06 | 8.26±3.24 | ||||
Block design | Intervention | 105 | 6.85±1.70 | 7.39±1.61 | 7.88±1.74 | <0.001 | 0.016 | <0.001 |
Control | 105 | 6.44±2.61 | 6.30±2.74 | 5.88±2.60 | ||||
Picture arrangement | Intervention | 105 | 8.34±2.04 | 8.92±2.06 | 9.78±2.19 | <0.001 | <0.001 | <0.001 |
Control | 105 | 7.85±2.44 | 8.53±2.52 | 6.94±2.43 | ||||
Object assembly | Intervention | 105 | 6.50±1.58 | 5.90±1.57 | 6.44±1.52 | 0.365 | <0.001 | 0.062 |
Control | 105 | 6.33±2.28 | 5.57±2.11 | 6.22±2.21 |
*Presented as mean±SD.
† P value for group (intervention vs control) derived from analysis of covariance adjusted for respective baseline value and for age, gender and education.
FSIQ, full scale IQ.