Prior deutetrabenazine (n=232) | Prior placebo (n=111) | All patients (N=343) | ||||
Patient demographics and clinical characteristics | ||||||
Mean | SE | Mean | SE | Mean | SE | |
Age (years) | 57.6 | 0.7 | 54.6 | 1.1 | 56.7 | 0.6 |
Weight (kg) | 82.5 | 1.4 | 83.3 | 1.9 | 82.8 | 1.1 |
TD duration (years) | 5.5 | 0.4 | 6.1 | 0.5 | 5.7 | 0.3 |
Baseline total AIMS score | 8.8 | 0.2 | 8.9 | 0.4 | 8.8 | 0.2 |
QTcF interval (ms) | 412.6 | 1.7 | 410.8 | 2.2 | 412.0 | 1.3 |
N | % | N | % | N | % | |
Female | 130 | 56 | 61 | 55 | 191 | 56 |
Caucasian | 182 | 78 | 88 | 79 | 270 | 79 |
Baseline use of DRA | 170 | 73 | 86 | 77 | 256 | 75 |
Typical antipsychotics | 15 | 6 | 4 | 4 | 19 | 6 |
Atypical antipsychotics | 136 | 59 | 77 | 69 | 213 | 62 |
Both | 19 | 8 | 5 | 5 | 24 | 7 |
Background c omorbid i llness | ||||||
Psychotic disorders | 139 | 60 | 66 | 59 | 205 | 60 |
Schizophrenia | 116 | 50 | 51 | 46 | 167 | 49 |
Schizoaffective disorder | 23 | 10 | 15 | 14 | 38 | 11 |
Mood disorders | 93 | 40 | 44 | 40 | 137 | 40 |
Bipolar | 35 | 15 | 28 | 25 | 63 | 18 |
Depression | 46 | 20 | 13 | 12 | 59 | 17 |
Other | 12 | 5 | 3 | 3 | 15 | 4 |
AIMS, Abnormal Involuntary Movement Scale; DRA, dopamine receptor-antagonist; QTcF, Fridericia-corrected QT interval; SE, standard error; TD, tardive dyskinesia.