Parameter | HR | 95% CI | P value |
NEDA-2 | 0.749 | 0.623 to 0.901 | 0.0021 |
Active disease | Ref | ||
Age at index date: 18–24 years | Reference | ||
Age at index date: 25–29 years | 0.764 | 0.548 to 1.065 | 0.1124 |
Age at index date: 30–34 years | 0.581 | 0.413 to 0.818 | 0.0018 |
Age at index date: 35–39 years | 0.575 | 0.406 to 0.815 | 0.0019 |
Age at index date: 40–44 | 0.676 | 0.474 to 0.966 | 0.0313 |
Age at index date:>44 | 0.962 | 0.683 to 1.355 | 0.8247 |
Disease duration | 1.038 | 1.002 to 1.075 | 0.0370 |
N of relapses 24 months before treatment start | 0.973 | 0.896 to 1.057 | 0.5208 |
Socioeconomic status: employee, low skilled | Reference | ||
Socioeconomic status: employee, moderate-high skilled | 0.615 | 0.495 to 0.765 | <0.0001 |
Socioeconomic status: chief executive in a public institution | 0.664 | 0.340 to 1.296 | 0.2302 |
Socioeconomic status: educational support | 1.111 | 0.776 to 1.590 | 0.5659 |
Socioeconomic status: leave of absence (sick leave and parental leave) | 2.023 | 1.314 to 3.116 | 0.0014 |
Socioeconomic status at treatment start: own Business | 1.892 | 1.047 to 3.419 | 0.0347 |
Socioeconomic status: unemployed for >6 months of the year | 1.225 | 0.746 to 2.013 | 0.4225 |
Socioeconomic status: other | 1.539 | 0.832 to 2.846 | 0.1693 |
Calendar year at treatment start | 0.972 | 0.943 to 1.003 | 0.0763 |
EDSS level at treatment start EDSS 0 | Reference | ||
EDSS level at treatment start EDSS 1–2.5 | 1.426 | 1.054 to 1.931 | 0.0216 |
EDSS level at treatment start EDSS 3–3.5 | 1.456 | 1.017 to 2.085 | 0.0401 |
EDSS level at treatment start EDSS 4–4.5 | 1.711 | 1.054 to 1.931 | 0.0678 |
EDSS, Expanded Disability Status Scale.